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Science 12 August 1983:
Vol. 221. no. 4611, pp. 667 - 669
DOI: 10.1126/science.6867736
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Articles

Science, Vol 221, Issue 4611, 667-669
Copyright © 1983 by American Association for the Advancement of Science

articles

Hepatitis B virus infection in cultured human lymphoblastoid cells

JL Romet-Lemonne, MF McLane, E Elfassi, WA Haseltine, J Azocar, and M Essex

Since it has been postulated that liver hepatocytes may become infected by hepatitis B virus (HBV) in vivo through direct contact with infected macrophages, the possibility that a circulating cell of hematopoietic origin might be susceptible to infection with HBV was investigated. Cells positive for HBV surface antigen were identified in aspirates of bone marrow cells from people infected with HBV. These cells were used to prepare a lymphoblastoid suspension culture that contains HBV-infected cells.


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Repeated Passage of Wild-Type Woodchuck Hepatitis Virus in Lymphoid Cells Does Not Generate Cell Type-Specific Variants or Alter Virus Infectivity.
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Alcohol Alters Luteinizing Hormone Secretion in Immature Female Rhesus Monkeys by a Hypothalamic Action.
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In Vivo Tropism of Hepatitis C Virus Genomic Sequences in Hematopoietic Cells: Influence of Viral Load, Viral Genotype, and Cell Phenotype.
H. Lerat, S. Rumin, F. Habersetzer, F. Berby, M.-A. Trabaud, C. Trepo, and G. Inchauspe (1998)
Blood 91, 3841-3849
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High-frequency transfection and cytopathology of the hepatitis B virus core antigen gene in human cells.
G. Yoakum, B. Korba, J. Lechner, T Tokiwa, A. Gazdar, T Seeley, M Siegel, L Leeman, H Autrup, and C. Harris (1983)
Science 222, 385-389
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