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Science 5 August 1983:
Vol. 221. no. 4610, pp. 564 - 566
DOI: 10.1126/science.6867729
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Articles

Science, Vol 221, Issue 4610, 564-566
Copyright © 1983 by American Association for the Advancement of Science

articles

The immune response evokes changes in brain noradrenergic neurons

H Besedovsky, A del Rey, E Sorkin, M Da Prada, R Burri, and C Honegger

A decreased noradrenaline turnover in the hypothalami of rats was observed at the peak of the immune response to sheep red blood cells. The decrease in noradrenergic neuronal activity was mimicked by injection of soluble r mediators released by immunological cells activated in vitro. Noradrenaline also tended to decrease in the brainstem but not in the residual brain. It is suggested that products released from activated immunological cells during the immune response may induce the previously described autonomic and endocrine mechanisms that contribute to immunoregulation.


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