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Science 5 August 1983:
Vol. 221. no. 4610, pp. 560 - 562
DOI: 10.1126/science.6408736
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Articles

Science, Vol 221, Issue 4610, 560-562
Copyright © 1983 by American Association for the Advancement of Science

articles

Coronary artery spasm induced in atherosclerotic miniature swine

H Shimokawa, H Tomoike, S Nabeyama, H Yamamoto, H Araki, M Nakamura, Y Ishii, and K Tanaka

Angiographically demonstrable coronary artery spasm could be provoked repeatedly by giving intracoronary or intravenous injections of histamine to miniature swine with experimentally induced atherosclerotic lesions of the coronary artery. The spasm induced in this way subsided either spontaneously or after the administration of nitroglycerin and was prevented by a calcium antagonist or an agent that blocks histamine H1 receptors. This model, which suggests that atherosclerotic changes may be one of the primary factors in the occurrence of coronary artery spasm, should facilitate studies on the pathogenesis of this condition.


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