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Science 5 August 1983:
Vol. 221. no. 4610, pp. 556 - 558
DOI: 10.1126/science.6408735
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Articles

Science, Vol 221, Issue 4610, 556-558
Copyright © 1983 by American Association for the Advancement of Science

articles

Potent interaction between glucocorticoids and growth hormone-releasing factor in vivo

WB Wehrenberg, A Baird, and N Ling

Administration of dexamethasone significantly enhanced the pituitary growth hormone response to growth hormone-releasing factor in intact as well as adrenalectomized rats. Thus the inhibitory effects of glucocorticosteroids on somatic growth which involve an interaction of these steroids and growth hormone at a peripheral level may also involve a modification of pathways within the central nervous system that regulate normal growth hormone secretion.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Regulation of Somatotroph Differentiation and Growth Hormone (GH) Secretion by Corticosterone and GH-Releasing Hormone during Embryonic Development.
C. E. Dean and T. E. Porter (1999)
Endocrinology 140, 1104-1110
   Abstract »    Full Text »
Pathophysiology of the Neuroregulation of Growth Hormone Secretion in Experimental Animals and the Human.
A. Giustina and J. D. Veldhuis (1998)
Endocr. Rev. 19, 717-797
   Abstract »    Full Text »
Glucocorticoids Regulate Pituitary Growth Hormone-Releasing Hormone Receptor Messenger Ribonucleic Acid Expression.
T. L. Miller and K. E. Mayo (1997)
Endocrinology 138, 2458-2465
   Abstract »    Full Text »    PDF »


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