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Science 29 July 1983:
Vol. 221. no. 4609, pp. 470 - 472
DOI: 10.1126/science.6683427
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Articles

Science, Vol 221, Issue 4609, 470-472
Copyright © 1983 by American Association for the Advancement of Science

articles

Fetal brain transplant: reduction of cognitive deficits in rats with frontal cortex lesions

R Labbe, A Firl Jr, EJ Mufson, and DG Stein

Frontal cortex and cerebellar tissue from fetal rats was implanted into the damaged frontal cortex of adults. Cognitive deficits in spatial alternation learning that follow bilateral destruction of medial frontal cortex were reduced in rats with frontal cortex implants but not in those with implants of cerebellum. Histological evaluation showed that connections were made between the frontal cortex implants and host brain tissue.


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