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Science 29 July 1983:
Vol. 221. no. 4609, pp. 462 - 464
DOI: 10.1126/science.6346487
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Articles

Science, Vol 221, Issue 4609, 462-464
Copyright © 1983 by American Association for the Advancement of Science

articles

Insulin receptor antiserum and plant lectins mimic the direct effects of insulin on nuclear envelope phosphorylation

F Purrello, DB Burnham, and ID Goldfine

Insulin directly inhibits protein phosphorylation in isolated rat liver nuclear envelopes. In the present studies, an antiserum to insulin receptor as well as the plant lectins concanavalin A and phytohemagglutinin mimicked insulin action in isolated nuclear envelopes. These studies suggest that insulin and agents that mimic it may directly regulate nuclear functions.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)