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Science 22 July 1983:
Vol. 221. no. 4608, pp. 374 - 376
DOI: 10.1126/science.221.4608.374
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Articles

Metabolic Detoxification: Mechanism of Insect Resistance to Plant Psoralens

G. WAYNE IVIE 1, DON L. BULL 1, ROSS C. BEIER 1, NAN W. PRYOR 1, and ERNEST H. OERTLI 1

1 Agricultural Research Service, U.S. Department of Agriculture, College Station, Texas 77841

Larvae of the black swallowtail butterfly, Papilio polyxenes Stoll, forage successfully on plants that contain high levels of photosensitizing psoralens. These insects rapidly detoxify psoralens, particularly in the midgut tissue prior to absorption, with the result that appreciable levels of unmetabolized phototoxin do not enter the body circulation where deleterious light-induced interactions with dermal or subdermal tissues would occur.

Submitted on November 22, 1982
Revised on March 24, 1983


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