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Science 22 July 1983:
Vol. 221. no. 4608, pp. 331 - 338
DOI: 10.1126/science.6306765
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Articles

Science, Vol 221, Issue 4608, 331-338
Copyright © 1983 by American Association for the Advancement of Science

articles

Protein phosphatases: properties and role in cellular regulation

TS Ingebritsen and P Cohen

Protein phosphorylation is a principal regulatory mechanism in the control of almost all cellular processes. The nature of the protein phosphatases that participate in these reactions has been a subject of controversy. Four enzymes, termed protein phosphatases 1, 2A, 2B, and 2C, account for virtually all of the phosphatase activity toward phosphoproteins involved in controlling glycogen metabolism, glycolysis, gluconeogenesis, fatty acid synthesis, cholesterol synthesis, and protein synthesis. The properties, physiological roles, and mechanisms for regulating the four protein phosphatases are reviewed.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)