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Science 15 July 1983:
Vol. 221. no. 4607, pp. 286 - 289
DOI: 10.1126/science.6134339
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Articles

Science, Vol 221, Issue 4607, 286-289
Copyright © 1983 by American Association for the Advancement of Science

articles

Peptide cotransmitter at a neuromuscular junction

ME Adams and M O'Shea

The neuropeptide proctolin (H-Arg-Tyr-Leu-Pro-Thr-OH) is present in the nerve terminals of an identified slow skeletal motoneuron in the cockroach. Proctolin is released onto the target muscle, a coxal depressor, by neuron stimulation and by depolarization with potassium. The physiological action of the motoneuron suggests that proctolin acts as a cotransmitter. Proctolin and neural stimulation produce delayed and sustained contractile effects without muscle depolarization.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The neuropeptide proctolin potentiates contractions and reduces cGMP concentration via a PKC-dependent pathway.
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Rapid Dopaminergic Signaling by Interneurons That Contain Markers for Catecholamines and GABA in the Feeding Circuitry of Aplysia.
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Colocalized Neuropeptides Activate a Central Pattern Generator by Acting on Different Circuit Targets.
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Resting Membrane Properties of Locust Muscle and Their Modulation I. Actions of the Neuropeptides YGGFMRFamide and Proctolin.
C. Walther, K. E. Zittlau, H. Murck, and K. Voigt (1998)
J Neurophysiol 80, 771-784
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Costorage and Corelease of Modulatory Peptide Cotransmitters with Partially Antagonistic Actions on the Accessory Radula Closer Muscle of Aplysia californica.
F. S. Vilim, D. A. Price, W. Lesser, I. Kupfermann, and K. R. Weiss (1996)
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Release of Peptide Cotransmitters in Aplysia: Regulation and Functional Implications.
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Identification of a peptide specific for Aplysia sensory neurons by PCR-based differential screening.
J. Brunet, E Shapiro, S. Foster, E. Kandel, and Y Iino (1991)
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Intracellular stimulation of an identified neuron evokes cardioacceleratory peptide release.
N. Tublitz and J. Truman (1985)
Science 228, 1013-1015
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