Science 15 July 1983: Vol. 221. no. 4607, pp. 275 - 277 DOI: 10.1126/science.6304883

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Articles

Efficient Serum-Free Derivation of Oligodendrocyte Precursors from Neural Stem Cell-Enriched Cultures.

R. C. Rao, J. Boyd, R. Padmanabhan, J. G. Chenoweth, and R. D. McKay (2009)
Stem Cells 27, 116-125
 |  Abstract »  |  Full Text »  |  PDF »

Human and mouse introns are linked to the same processes and functions through each genome's most frequent non-conserved motifs.

A. Tsirigos and I. Rigoutsos (2008)
Nucleic Acids Res. 36, 3484-3493
 |  Abstract »  |  Full Text »  |  PDF »

Role of platelet-derived growth factors in physiology and medicine.

J. Andrae, R. Gallini, and C. Betsholtz (2008)
Genes & Dev. 22, 1276-1312
 |  Abstract »  |  Full Text »  |  PDF »

Transforming signals resulting from sustained activation of the PDGF{beta} receptor in mortal human fibroblasts.

L. M. Petti, E. C. Ricciardi, H. J. Page, and K. A. Porter (2008)
J. Cell Sci. 121, 1172-1182
 |  Abstract »  |  Full Text »  |  PDF »

Biology of Platelet-Derived Growth Factor and Its Involvement in Disease.

R. H. Alvarez, H. M. Kantarjian, and J. E. Cortes (2006)
Mayo Clin. Proc. 81, 1241-1257
 |  Abstract »  |  Full Text »  |  PDF »

Malignant Transformation of Human Cells by Constitutive Expression of Platelet-derived Growth Factor-BB.

B. Govindarajan, A. Shah, C. Cohen, R. S. Arnold, J. Schechner, J. Chung, A. M. Mercurio, R. Alani, B. Ryu, C.-Y. Fan, et al. (2005)
J. Biol. Chem. 280, 13936-13943
 |  Abstract »  |  Full Text »  |  PDF »

A Potential Oncogenic Activity of Platelet-Derived Growth Factor D in Prostate Cancer Progression.

C. V. Ustach, M. E. Taube, N. J. Hurst Jr., S. Bhagat, R. D. Bonfil, M. L. Cher, L. Schuger, and H.-R. C. Kim (2004)
Cancer Res. 64, 1722-1729
 |  Abstract »  |  Full Text »  |  PDF »

Cloning, Expression, Characterization, and Role in Autocrine Cell Growth of Cell Surface Retention Sequence Binding Protein-1.

S. S. Huang, F.-M. Tang, Y.-H. Huang, I-H. Liu, S.-C. Hsu, S.-T. Chen, and J. S. Huang (2003)
J. Biol. Chem. 278, 43855-43869
 |  Abstract »  |  Full Text »  |  PDF »

Roles of PDGF in animal development.

R. V. Hoch and P. Soriano (2003)
Development 130, 4769-4784
 |  Abstract »  |  Full Text »  |  PDF »

Overexpression of the Sis Oncogene in a Canine Osteosarcoma Cell Line.

R. A. Levine (2002)
Vet. Pathol. 39, 411-412
 |  Abstract »  |  Full Text »  |  PDF »

Triplex targeting of human PDGF-B (c-sis, proto-oncogene) promoter specifically inhibits factors binding and PDGF-B transcription.

J. Liu, R.-H. Xu, Y.-X. Jin, and D.-B. Wang (2001)
Nucleic Acids Res. 29, 783-791
 |  Abstract »  |  Full Text »  |  PDF »

Upregulation of Tyrosine Kinase TKT by the Epstein-Barr Virus Transactivator Zta.

J. Lu, S.-Y. Chen, H.-H. Chua, Y.-S. Liu, Y.-T. Huang, Y. Chang, J.-Y. Chen, T.-S. Sheen, and C.-H. Tsai (2000)
J. Virol. 74, 7391-7399
 |  Abstract »  |  Full Text »

Blockade of Receptors for Growth Factors: An Anticancer Therapy -- The Fourth Annual Joseph H. Burchenal American Association for Cancer Research Clinical Research Award Lecture.

J. Mendelsohn (2000)
Clin. Cancer Res. 6, 747-753
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E5 Oncoprotein Mutants Activate Phosphoinositide 3-Kinase Independently of Platelet-derived Growth Factor Receptor Activation.

F. A. Suprynowicz, J. Sparkowski, A. Baege, and R. Schlegel (2000)
J. Biol. Chem. 275, 5111-5119
 |  Abstract »  |  Full Text »  |  PDF »

The Dermatofibrosarcoma Protuberans-associated Collagen Type I{{alpha}}1/Platelet-derived Growth Factor (PDGF) B-Chain Fusion Gene Generates a Transforming Protein That Is Processed to Functional PDGF-BB.

A. Shimizu, K. P. O'Brien, T. Sjoblom, K. Pietras, E. Buchdunger, V. P. Collins, C.-H. Heldin, J. P. Dumanski, and A. Ostman (1999)
Cancer Res. 59, 3719-3723
 |  Abstract »  |  Full Text »  |  PDF »

Cell Surface Retention Sequence Binding Protein-1 Interacts with the v-sis Gene Product and Platelet-derived Growth Factor beta -Type Receptor in Simian Sarcoma Virus-transformed Cells.

C. Boensch, S. S. Huang, D. T. Connolly, and J. S. Huang (1999)
J. Biol. Chem. 274, 10582-10589
 |  Abstract »  |  Full Text »  |  PDF »

Phase I and Pharmacologic Study of the Tyrosine Kinase Inhibitor SU101 in Patients With Advanced Solid Tumors.

S. G. Eckhardt, J. Rizzo, K. R. Sweeney, G. Cropp, S. D. Baker, J. G. Kuhn, M. A. Villalona-Calero, L. Hammond, G. Weiss, A. Thurman, et al. (1999)
J. Clin. Oncol. 17, 1095
 |  Abstract »  |  Full Text »  |  PDF »

Influence of hypoxia in inflammatory synovitis.

T Bodamyali, C R Stevens, M E J Billingham, S Ohta, and D R Blake (1998)
Ann Rheum Dis 57, 703-710
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The Pathways Connecting G Protein-coupled Receptors to the Nucleus through Divergent Mitogen-activated Protein Kinase Cascades.

J. S. Gutkind (1998)
J. Biol. Chem. 273, 1839-1842
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The Tax Protein of Human T-cell Leukemia Virus Type 1 Mediates the Transactivation of the c-sis/Platelet-derived Growth Factor-B Promoter through Interactions with the Zinc Finger Transcription Factors Sp1 and NGFI-A/Egr-1.

S. R. Trejo, W. E. Fahl, and L. Ratner (1997)
J. Biol. Chem. 272, 27411-27421
 |  Abstract »  |  Full Text »  |  PDF »

Platelet-Derived Growth Factor and Arterial Response to Injury.

C. E. Hart and A. W. Clowes (1997)
Circulation 95, 555-556
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Stat6 and Jak1 Are Common Elements in Platelet-derived Growth Factor and Interleukin-4 Signal Transduction Pathways in NIH 3T3 Fibroblasts.

B. K.R. Patel, L.-M. Wang, C.-C. Lee, W. G. Taylor, J. H. Pierce, and W. J. LaRochelle (1996)
J. Biol. Chem. 271, 22175-22182
 |  Abstract »  |  Full Text »  |  PDF »

c-sis/PDGF-B Promoter Transactivation by the Tax Protein of Human T-cell Leukemia Virus Type 1.

S. R. Trejo, W. E. Fahl, and L. Ratner (1996)
J. Biol. Chem. 271, 14584-14590
 |  Abstract »  |  Full Text »  |  PDF »

Transcriptional Regulation of the SIS/PDGF-B Gene in Human Osteosarcoma Cells by the Sp Family of Transcription Factors.

Y. Liang, D. F. Robinson, Jör. Dennig, G. Suske, and W. E. Fahl (1996)
J. Biol. Chem. 271, 11792-11797
 |  Abstract »  |  Full Text »  |  PDF »

Identification of a Thrombin Response Element in the Human Platelet-derived Growth Factor B-chain (c-sis) Promoter.

E. M. Scarpati and P. E. DiCorleto (1996)
J. Biol. Chem. 271, 3025-3032
 |  Abstract »  |  Full Text »  |  PDF »

Expression and Function of a Recombinant PDGF B Gene in Porcine Arteries.

V. J. Pompili, D. Gordon, H. San, Z. Yang, D. W.M. Muller, G. J. Nabel, and E. G. Nabel (1995)
Arterioscler. Thromb. Vasc. Biol. 15, 2254-2264
 |  Abstract »  |  Full Text »

Compartmentalization of Autocrine Signal Transduction Pathways in Sis-transformed NIH 3T3 Cells.

S. Valgeirsdóttir, A. Eriksson, M. Nistér, C.-H. Heldin, B. Westermark, and L. Claesson-Welsh (1995)
J. Biol. Chem. 270, 10161-10170
 |  Abstract »  |  Full Text »  |  PDF »

Identification, Purification, and Characterization of Cell-surface Retention Sequence-binding Proteins from Human SK-Hep Cells and Bovine Liver Plasma Membranes.

C. Boensch, M.-D. Kuo, D. T. Connolly, S. S. Huang, and J. S. Huang (1995)
J. Biol. Chem. 270, 1807-1816
 |  Abstract »  |  Full Text »  |  PDF »

Monocyte Infiltration and c-fms Expression in Hearts of Spontaneously Hypertensive Rats.

H. Haller, M. Behrend, J. K. Park, T. Schaberg, F. C. Luft, and A. Distler (1995)
Hypertension 25, 132-138
 |  Abstract »  |  Full Text »

Platelet-derived growth factor-A and its receptor are expressed in separate, but adjacent cell layers of the mouse embryo.

A Orr-Urtreger and P Lonai (1992)
Development 115, 1045-1058
 |  Abstract »  |  PDF »

Growth factors and cancer.

S. Aaronson (1991)
Science 254, 1146-1153
 |  Abstract »  |  PDF »

A novel mechanism regulating growth factor association with the cell surface: identification of a PDGF retention domain..

W J LaRochelle, M May-Siroff, K C Robbins, and S A Aaronson (1991)
Genes & Dev. 5, 1191-1199
 |  Abstract »  |  PDF »

Oncogenes: The Growth Control Genes.

S. R. Feldman and M. Yaar (1991)
Arch Dermatol 127, 707-711
 |  Abstract »  |  PDF »

Dominant-negative mutants of a platelet-derived growth factor gene..

M Mercola, P L Deininger, S M Shamah, J Porter, C Y Wang, and C D Stiles (1990)
Genes & Dev. 4, 2333-2341
 |  Abstract »  |  PDF »

Molecular localization of the transforming and secretory properties of PDGF A and PDGF B.

W. LaRochelle, N Giese, M May-Siroff, K. Robbins, and S. Aaronson (1990)
Science 248, 1541-1544
 |  Abstract »  |  PDF »

Regulation of Proto-Oncogenes and Salivary Gland Cell Proliferation.

E. Kousvelari, C.-K. Yeh, P.M. Mertz, and M. Chinchetru (1990)
Advances in Dental Research 4, 61-68
 |  Abstract »  |  PDF »

Orchestrating the Human Genome Project.

C. Cantor (1990)
Science 248, 49-51
 |  Abstract »  |  PDF »

Mesenchymal Cell Growth Factors.

D. T. Graves and D. L. Cochran (1990)
Critical Reviews in Oral Biology & Medicine 1, 17-36
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Vascular permeability factor, an endothelial cell mitogen related to PDGF.

P. Keck, S. Hauser, G Krivi, K Sanzo, T Warren, J Feder, and D. Connolly (1989)
Science 246, 1309-1312
 |  Abstract »  |  PDF »

Transformation by v-sis occurs by an internal autoactivation mechanism.

B. Bejcek, D. Li, and T. Deuel (1989)
Science 245, 1496-1499
 |  Abstract »  |  PDF »

Specific expression of nuclear proto-oncogenes before entry into meiotic prophase of spermatogenesis.

H Wolfes, K Kogawa, C. Millette, and G. Cooper (1989)
Science 245, 740-743
 |  Abstract »  |  PDF »

Signal transduction by the platelet-derived growth factor receptor.

L. Williams (1989)
Science 243, 1564-1570
 |  Abstract »  |  PDF »

Comparison of biological properties and transforming potential of human PDGF-A and PDGF-B chains.

M. Beckmann, C Betsholtz, C. Heldin, B Westermark, E Di Marco, P. Di Fiore, K. Robbins, and S. Aaronson (1988)
Science 241, 1346-1349
 |  Abstract »  |  PDF »

Cellular transcription factors and regulation of IL-2 receptor gene expression by HTLV-I tax gene product.

S Ruben, H Poteat, T. Tan, K Kawakami, R Roeder, W Haseltine, and C. Rosen (1988)
Science 241, 89-92
 |  Abstract »  |  PDF »

Retroviruses.

H Varmus (1988)
Science 240, 1427-1435
 |  Abstract »  |  PDF »

Fos-associated protein p39 is the product of the jun proto-oncogene.

F. Rauscher 3rd, D. Cohen, T Curran, T. Bos, P. Vogt, D Bohmann, R Tjian, and B. Franza Jr (1988)
Science 240, 1010-1016
 |  Abstract »  |  PDF »

Computers in molecular biology: current applications and emerging trends.

C DeLisi (1988)
Science 240, 47-52
 |  Abstract »  |  PDF »

Autocrine stimulation of intracellular PDGF receptors in v-sis-transformed cells.

M. Keating and L. Williams (1988)
Science 239, 914-916
 |  Abstract »  |  PDF »

Oncogenes and transcriptional control.

H. Varmus (1987)
Science 238, 1337-1339
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The nerve growth factor 35 years later.

R Levi-Montalcini (1987)
Science 237, 1154-1162
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erbB-2 is a potent oncogene when overexpressed in NIH/3T3 cells.

P. Di Fiore, J. Pierce, M. Kraus, O Segatto, C. King, and S. Aaronson (1987)
Science 237, 178-182
 |  Abstract »  |  PDF »

The role of individual cysteine residues in the structure and function of the v-sis gene product.

N. Giese, K. Robbins, and S. Aaronson (1987)
Science 236, 1315-1318
 |  Abstract »  |  PDF »

Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene.

D. Slamon, G. Clark, S. Wong, W. Levin, A Ullrich, and W. McGuire (1987)
Science 235, 177-182
 |  Abstract »  |  PDF »

A novel human gene closely related to the abl proto-oncogene.

G. Kruh, C. King, M. Kraus, N. Popescu, S. Amsbaugh, W. McBride, and S. Aaronson (1986)
Science 234, 1545-1548
 |  Abstract »  |  PDF »

Diminished response of Werner's syndrome fibroblasts to growth factors PDGF and FGF.

E. Bauer, N Silverman, D. Busiek, A Kronberger, and T. Deuel (1986)
Science 234, 1240-1243
 |  Abstract »  |  PDF »

Early signals in the mitogenic response.

E Rozengurt (1986)
Science 234, 161-166
 |  Abstract »  |  PDF »

The complete primary structure of protein kinase C--the major phorbol ester receptor.

P. Parker, L Coussens, N Totty, L Rhee, S Young, E Chen, S Stabel, M. Waterfield, and A Ullrich (1986)
Science 233, 853-859
 |  Abstract »  |  PDF »

Induction of the c-fos oncogene by thyrotropic hormone in rat thyroid cells in culture.

G Colletta, A. Cirafici, and G Vecchio (1986)
Science 233, 458-460
 |  Abstract »  |  PDF »

Transmural Electrical Potential Difference as an Early Marker in Colon Cancer.

D. A. Goller, W. F. Weidema, and R. J. Davies (1986)
Arch Surg 121, 345-350
 |  Abstract »  |  PDF »

Human Steroid Receptors and erbA Proto-oncogene Products: Members of a New Superfamily of Enhancer Binding Proteins.

C. Weinberger, V. Giguere, S. Hollenberg, M.G. Rosenfeld, and R.M. Evans (1986)
Cold Spring Harb Symp Quant Biol 51, 759-772
 |  Abstract »  |  PDF »

Chromosomal Mapping of Genes Involved in Growth Control.

U. Francke, T.L. Yang-Feng, J.E. Brissenden, and A. Ullrich (1986)
Cold Spring Harb Symp Quant Biol 51, 855-866
 |  Abstract »  |  PDF »

Oncogenic Potential of the Human Platelet-derived Growth Factor Transcriptional Unit.

C.D. Rao, H. Igarashi, M.W. Pech, K.C. Robbins, and S.A. Aaronson (1986)
Cold Spring Harb Symp Quant Biol 51, 959-966
 |  Abstract »  |  PDF »

Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene.

L Coussens, T. Yang-Feng, Y. Liao, E Chen, A Gray, J McGrath, P. Seeburg, T. Libermann, J Schlessinger, U Francke, et al. (1985)
Science 230, 1132-1139
 |  Abstract »  |  PDF »

The action of oncogenes in the cytoplasm and nucleus.

R. Weinberg (1985)
Science 230, 770-776
 |  Abstract »  |  PDF »

Wounding and its role in RSV-mediated tumor formation.

D. Dolberg, R Hollingsworth, M Hertle, and M. Bissell (1985)
Science 230, 676-678
 |  Abstract »  |  PDF »

Evidence that the v-sis gene product transforms by interaction with the receptor for platelet-derived growth factor.

F Leal, L. Williams, K. Robbins, and S. Aaronson (1985)
Science 230, 327-330
 |  Abstract »  |  PDF »

Superinduction of c-fos by nerve growth factor in the presence of peripherally active benzodiazepines.

T Curran and J. Morgan (1985)
Science 229, 1265-1268
 |  Abstract »  |  PDF »

Amplification of a novel v-erbB-related gene in a human mammary carcinoma.

C. King, M. Kraus, and S. Aaronson (1985)
Science 229, 974-976
 |  Abstract »  |  PDF »

Microinjected c-myc as a competence factor.

L Kaczmarek, J. Hyland, R Watt, M Rosenberg, and R Baserga (1985)
Science 228, 1313-1315
 |  Abstract »  |  PDF »

Modulation of the sis gene transcript during endothelial cell differentiation in vitro.

M Jaye, E McConathy, W Drohan, B Tong, T Deuel, and T Maciag (1985)
Science 228, 882-885
 |  Abstract »  |  PDF »

Rapid and sensitive protein similarity searches.

D. Lipman and W. Pearson (1985)
Science 227, 1435-1441
 |  Abstract »  |  PDF »

Proto-Oncogene fos Is Expressed during Development, Differentiation, and Growth.

J. Deschamps, R.L. Mitchell, F. Meijlink, W. Kruijer, D. Schubert, and I.M. Verma (1985)
Cold Spring Harb Symp Quant Biol 50, 733-745
 |  Abstract »  |  PDF »

Requirement for a signal sequence in biological expression of the v-sis oncogene.

M Hannink and D. Donoghue (1984)
Science 226, 1197-1199
 |  Abstract »  |  PDF »

Expression of the c-fos gene and of an fos-related gene is stimulated by platelet-derived growth factor.

B. Cochran, J Zullo, I. Verma, and C. Stiles (1984)
Science 226, 1080-1082
 |  Abstract »  |  PDF »

Detection of c-sis transcripts and synthesis of PDGF-like proteins by human osteosarcoma cells.

D. Graves, A. Owen, R. Barth, P Tempst, A Winoto, L Fors, L. Hood, and H. Antoniades (1984)
Science 226, 972-974
 |  Abstract »  |  PDF »

Detection of high molecular weight forms of platelet-derived growth factor by sequence-specific antisera.

H. Niman, R. Houghten, and D. Bowen-Pope (1984)
Science 226, 701-703
 |  Abstract »  |  PDF »

Contemporary methodology for protein structure determination.

M. Hunkapiller, J. Strickler, and K. Wilson (1984)
Science 226, 304-311
 |  Abstract »  |  PDF »

Transforming potential of human c-sis nucleotide sequences encoding platelet-derived growth factor.

S. Josephs, L Ratner, M. Clarke, E. Westin, M. Reitz, and F Wong-Staal (1984)
Science 225, 636-639
 |  Abstract »  |  PDF »

Oncogenes: Implications for the Diagnosis and Treatment of Cancer.

M. J. CLINE, D. J. SLAMON, and J. S. LIPSICK (1984)
Ann Intern Med 101, 223-233
 |  Abstract »  |  PDF »

Simian sarcoma virus--transformed cells secrete a mitogen identical to platelet-derived growth factor.

A. Owen, P Pantazis, and H. Antoniades (1984)
Science 225, 54-56
 |  Abstract »  |  PDF »

Expression cloning of human EGF receptor complementary DNA: gene amplification and three related messenger RNA products in A431 cells.

C. Lin, W. Chen, W Kruiger, L. Stolarsky, W Weber, R. Evans, I. Verma, G. Gill, and M. Rosenfeld (1984)
Science 224, 843-848
 |  Abstract »  |  PDF »

Primary structure of v-raf: relatedness to the src family of oncogenes.

G. Mark and U. Rapp (1984)
Science 224, 285-289
 |  Abstract »  |  PDF »

Human-proto-oncogene nucleotide sequences corresponding to the transforming region of simian sarcoma virus.

S. Josephs, C Guo, L Ratner, and F Wong-Staal (1984)
Science 223, 487-491
 |  Abstract »  |  PDF »

Gene for T-cell growth factor: location on human chromosome 4q and feline chromosome B1.

L. Seigel, M. Harper, F Wong-Staal, R. Gallo, W. Nash, and S. O'Brien (1984)
Science 223, 175-178
 |  Abstract »  |  PDF »

The human gene for the beta subunit of nerve growth factor is located on the proximal short arm of chromosome 1.

U Francke, B de Martinville, L Coussens, and A Ullrich (1983)
Science 222, 1248-1251
 |  Abstract »  |  PDF »

Expression of a platelet-derived growth factor-like protein in simian sarcoma virus transformed cells.

T. Deuel, J. Huang, S. Huang, P Stroobant, and M. Waterfield (1983)
Science 221, 1348-1350
 |  Abstract »  |  PDF »

Genetic mapping of the mouse proto-oncogene c-sis to chromosome 15.

C. Kozak, J. Sears, and M. Hoggan (1983)
Science 221, 867-869
 |  Abstract »  |  PDF »

Onc gene related to growth factor gene.

J. Marx (1983)
Science 221, 248
 |  PDF »

NM23-H1 and NM23-H2 Repress Transcriptional Activities of Nuclease-hypersensitive Elements in the Platelet-derived Growth Factor-A Promoter.

D. Ma, Z. Xing, B. Liu, N. G. Pedigo, S. G. Zimmer, Z. Bai, E. H. Postel, and D. M. Kaetzel (2002)
J. Biol. Chem. 277, 1560-1567
 |  Abstract »  |  Full Text »  |  PDF »

Platelet-derived Growth Factor (PDGF) Receptor-alpha Activates c-Jun NH2-terminal Kinase-1 and Antagonizes PDGF Receptor-beta -induced Phenotypic Transformation.

J. Yu, T. F. Deuel, and H.-R. C. Kim (2000)
J. Biol. Chem. 275, 19076-19082
 |  Abstract »  |  Full Text »  |  PDF »

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