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Science 15 July 1983:
Vol. 221. no. 4607, pp. 273 - 274
DOI: 10.1126/science.6574604
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Articles
Science, Vol 221, Issue 4607, 273-274
Copyright © 1983 by American Association for the Advancement of Science
Inhibitory role of the endothelium in the response of isolated coronary arteries to platelets
RA Cohen,
JT Shepherd,
and
PM Vanhoutte
Aggregating autologous platelets caused contraction of isolated rings of canine left circumflex arteries. The contractions were augmented after removal of the endothelium and were attenuated by serotonergic antagonists. During contraction caused by prostaglandin F2 alpha, aggregating platelets caused a transient increase in tension followed by a profound relaxation of arteries with endothelium, but caused only further contraction of arteries without endothelium. These observations demonstrate the importance of the vascular endothelium in opposing the constriction of coronary vessels caused by 5-hydroxytryptamine and other substances released from aggregating platelets.
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