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Science 8 July 1983:
Vol. 221. no. 4606, pp. 188 - 190
DOI: 10.1126/science.6344221
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Articles

Science, Vol 221, Issue 4606, 188-190
Copyright © 1983 by American Association for the Advancement of Science

articles

Insulin elicits ingestion in decerebrate rats

FW Flynn and HJ Grill

Insulin administered to rats reliably elicits ingestion of food. To determine whether the neural mechanisms sufficient to control insulin-elicited ingestion are located in or caudal to the forebrain, decerebrate rats were treated with insulin and ingestive responses were measured. Insulin treatment produced hypoglycemia that was comparable, in magnitude and duration, in control and decerebrate rats. Decerebrate and control rats ingested significantly more sucrose solution while hypoglycemic than while normoglycemic. In contrast, insulin did not augment the water consumption of either group. These data indicate that neural systems caudal to the forebrain are sufficient to control ingestive consummatory behavior through the integration of metabolic signals generated by insulin treatment and taste afferent input from the oropharynx.


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