Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 8 July 1983:
Vol. 221. no. 4606, pp. 173 - 175
DOI: 10.1126/science.6304881
Prev | Table of Contents | Next

Articles

Science, Vol 221, Issue 4606, 173-175
Copyright © 1983 by American Association for the Advancement of Science

articles

Herpes simplex virus glycoprotein D: human monoclonal antibody produced by bone marrow cell line

JM Seigneurin, C Desgranges, D Seigneurin, J Paire, JC Renversez, B Jacquemont, and C Micouin

Normal bone marrow cells from a donor positive for herpes simplex virus were transformed with Epstein-Barr virus. The resulting lymphoblastoid cell line has secreted immunoglobulin G1 of the kappa type continuously for 2 years. This immunoglobulin, detected both on the cell surface and in the cytoplasm, reacts with cells infected with herpes simplex virus. It defines an antigen that comigrates with the 55-kilodalton glycoprotein D of herpes simplex virus type 1 and neutralizes the infectivity of herpes simplex viruses 1 and 2.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Major Neutralizing Antigenic Site on Herpes Simplex Virus Glycoprotein D Overlaps a Receptor-Binding Domain.
J. C. Whitbeck, M. I. Muggeridge, A. H. Rux, W. Hou, C. Krummenacher, H. Lou, A. van Geelen, R. J. Eisenberg, and G. H. Cohen (1999)
J. Virol. 73, 9879-9890
   Abstract »    Full Text »
Functional Region IV of Glycoprotein D from Herpes Simplex Virus Modulates Glycoprotein Binding to the Herpesvirus Entry Mediator.
A. H. Rux, S. H. Willis, A. V. Nicola, W. Hou, C. Peng, H. Lou, G. H. Cohen, and R. J. Eisenberg (1998)
J. Virol. 72, 7091-7098
   Abstract »    Full Text »    PDF »
Monoclonal Antibodies to Distinct Sites on Herpes Simplex Virus (HSV) Glycoprotein D Block HSV Binding to HVEM.
A. V. Nicola, M. Ponce de Leon, R. Xu, W. Hou, J. C. Whitbeck, C. Krummenacher, R. I. Montgomery, P. G. Spear, R. J. Eisenberg, and G. H. Cohen (1998)
J. Virol. 72, 3595-3601
   Abstract »    Full Text »    PDF »
PRESERVATION OF ENDOTHELIUM-DEPENDENT VASODILATION WITH LOW-POTASSIUM UNIVERSITY OF WISCONSIN SOLUTION.
J. Lee, D. C. Drinkwater Jr., H. Laks, A. Chong, A. Blitz, M. A. Chen, L. J. Ignarro, and P. Chang (1996)
J. Thorac. Cardiovasc. Surg. 112, 103-110
   Abstract »    Full Text »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)