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Science 8 July 1983:
Vol. 221. no. 4606, pp. 167 - 169
DOI: 10.1126/science.6857276
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Articles

Science, Vol 221, Issue 4606, 167-169
Copyright © 1983 by American Association for the Advancement of Science

articles

Combined lipase deficiency (cld): a lethal mutation on chromosome 17 of the mouse

JR Paterniti Jr, WV Brown, HN Ginsberg, and K Artzt

Two triglyceride lipases, lipoprotein lipase and hepatic triglyceride lipase, participate in the metabolism of plasma lipoproteins. A single recessive mutation, cld, on mouse chromosome 17 causes an apparent deficiency of both lipoprotein lipase and hepatic triglyceride lipase activities. Mice homozygous for this defect develop lethal hyperchylomicronemia within 2 days postpartum as a consequence of nursing. Plasma triglyceride values in affected mice often reach 20,000 milligrams per deciliter (100 times higher than that in normal littermates), and total lipase activity in plasma or tissues is 5 to 20 percent of that in controls.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Differential effect of combined lipase deficiency (cld/cld) on human hepatic lipase and lipoprotein lipase secretion.
J. C. Boedeker, M. H. Doolittle, and A. L. White (2001)
J. Lipid Res. 42, 1858-1864
   Abstract »    Full Text »    PDF »
Adrenal and liver in normal and cld/cld mice synthesize and secrete hepatic lipase, but the lipase is inactive in cld/cld mice.
C. J. Schultz, E. J. Blanchette-Mackie, and R. O. Scow (2000)
J. Lipid Res. 41, 214-225
   Abstract »    Full Text »
cld and lec23 are disparate mutations that affect maturation of lipoprotein lipase in the endoplasmic reticulum.
V. Briquet-Laugier, O. Ben-Zeev, A. White, and M. H. Doolittle (1999)
J. Lipid Res. 40, 2044-2058
   Abstract »    Full Text »
Chylomicron metabolism in an animal model for hyperlipoproteinemia type I.
R. Savonen, K. Nordstoga, B. Christophersen, A. Lindberg, Y. Shen, M. Hultin, T. Olivecrona, and G. Olivecrona (1999)
J. Lipid Res. 40, 1336-1346
   Abstract »    Full Text »
COOH-terminal Disruption of Lipoprotein Lipase in Mice Is Lethal in Homozygotes, but Heterozygotes Have Elevated Triglycerides and Impaired Enzyme Activity.
T. Coleman, R. L. Seip, J. M. Gimble, D. Lee, N. Maeda, and C. F. Semenkovich (1995)
J. Biol. Chem. 270, 12518-12525
   Abstract »    Full Text »    PDF »
Adenovirus-mediated Rescue of Lipoprotein Lipase-deficient Mice. LIPOLYSIS OF TRIGLYCERIDE-RICH LIPOPROTEINS IS ESSENTIAL FOR HIGH DENSITY LIPOPROTEIN MATURATION IN MICE.
J. G. Strauss, S. Frank, D. Kratky, G. Hammerle, A. Hrzenjak, G. Knipping, A. von Eckardstein, G. M. Kostner, and R. Zechner (2001)
J. Biol. Chem. 276, 36083-36090
   Abstract »    Full Text »    PDF »


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