Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 8 July 1983:
Vol. 221. no. 4606, pp. 155 - 157
DOI: 10.1126/science.6344220
Prev | Table of Contents | Next

Articles

Science, Vol 221, Issue 4606, 155-157
Copyright © 1983 by American Association for the Advancement of Science

articles

Nucleotide sequence of the Rasheed rat sarcoma virus oncogene: new mutations

S Rasheed, GL Norman, and G Heidecker

The nucleotide sequence of the oncogene of the Rasheed strain of rat sarcoma virus was determined. The oncogene (Ra-v-ras) encodes a 29,000-dalton (p29) transforming protein. This protein is distinct from the immunologically related 21,000-dalton protein (p21) of the Harvey murine sarcoma virus in its amino terminus and in having additional mutations in its carboxyl terminus. Although the functional significance of these changes is unknown, they appear to occur only in rat sarcoma virus.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Genetic Analysis of the Rat Leukemia Virus: Influence of Viral Sequences in Transduction of the c-ras Proto-Oncogene and Expression of Its Transforming Activity.
S.-Y. Lee, T. M. Howard, and S. Rasheed (1998)
J. Virol. 72, 9906-9917
   Abstract »    Full Text »    PDF »
Activation of the cellular proto-oncogene product p21Ras by addition of a myristylation signal.
J. Buss, P. Solski, J. Schaeffer, M. MacDonald, and C. Der (1989)
Science 243, 1600-1603
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)