Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 1 July 1983:
Vol. 221. no. 4605, pp. 77 - 79
DOI: 10.1126/science.6304879
Prev | Table of Contents | Next

Articles

Science, Vol 221, Issue 4605, 77-79
Copyright © 1983 by American Association for the Advancement of Science

articles

Metabolism of polycyclic aromatic hydrocarbon derivatives to ultimate carcinogens during lipid peroxidation

TA Dix and LJ Marnett

Lipid peroxidation triggered by ascorbate or reduced nicotinamide adenine dinucleotide in rat liver microsomes can initiate the epoxidation of 7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene. The stereochemistry of epoxidation is indicative of a peroxide-dependent free radical process. Since the epoxides formed may be the most carcinogenic derivatives of benzo[a]pyrene yet identified, lipid peroxidation can effect the metabolic activation of proximate carcinogens to ultimate carcinogens.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Growing Burden of Chronic Obstructive Pulmonary Disease and Lung Cancer in Women: Examining Sex Differences in Cigarette Smoke Metabolism.
S. Ben-Zaken Cohen, P. D. Pare, S. F. P. Man, and D. D. Sin (2007)
Am. J. Respir. Crit. Care Med. 176, 113-120
   Abstract »    Full Text »    PDF »
Myeloperoxidase - 463A variant reduces benzo[a]pyrene diol epoxide DNA adducts in skin of coal tar treated patients.
M. Rojas, R. Godschalk, K. Alexandrov, I. Cascorbi, E. Kriek, J. Ostertag, F.-J. Van Schooten, and H. Bartsch (2001)
Carcinogenesis 22, 1015-1018
   Abstract »    Full Text »    PDF »
Detection of endogenous malondialdehyde-deoxyguanosine adducts in human liver.
A. Chaudhary, M Nokubo, G. Reddy, S. Yeola, J. Morrow, I. Blair, and L. Marnett (1994)
Science 265, 1580-1582
   Abstract »    PDF »
The Role of Metabolism in Chemical-Induced Pulmonary Toxicity*1.
B. R. Smith and W. R. Brian (1991)
Toxicol Pathol 19, 470-481
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)