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Science 1 July 1983:
Vol. 221. no. 4605, pp. 65 - 67
DOI: 10.1126/science.6857264
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Articles

Science, Vol 221, Issue 4605, 65-67
Copyright © 1983 by American Association for the Advancement of Science

articles

Redox delivery system for brain-specific, sustained release of dopamine

N Bodor and JW Simpkins

Dopamine was transformed into a redox chemical system for delivery to the brain. The lipoidal form allowed penetration of the blood-brain barrier. Oxidative and hydrolytic processes then transformed the delivery form into a quaternary ammonium precursor of dopamine. The quaternary ammonium precursor was rapidly eliminated from the general circulation, whereas that formed in the brain was locked in, thereby providing a significant and sustained brain-specific dopaminergic activity.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)