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Science 24 June 1983:
Vol. 220. no. 4604, pp. 1401 - 1403
DOI: 10.1126/science.6602380
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Articles

Science, Vol 220, Issue 4604, 1401-1403
Copyright © 1983 by American Association for the Advancement of Science

articles

Behavioral disease in rats caused by immunopathological responses to persistent borna virus in the brain

O Narayan, S Herzog, K Frese, H Scheefers, and R Rott

Borna virus replicated persistently in the brains of rats, causing frenzied and apathetic behavioral states in sequence but no mortality. The transient frenzied behavior was caused by an immune-mediated, cytolytic, encephalitic response that was unexpectedly self-limiting. Cessation of active pathological processes coincided with the onset of the passive phase of the disease. This study thus demonstrates suppression of virus-specific inflammation despite continuous viral replication and describes a new mechanism by which chronic encephalitis may become established.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Hippocampal Poly(ADP-Ribose) Polymerase 1 and Caspase 3 Activation in Neonatal Bornavirus Infection.
B. L. Williams, M. Hornig, K. Yaddanapudi, and W. I. Lipkin (2008)
J. Virol. 82, 1748-1758
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Viruses as an Etiology of Obesity.
R. L. Atkinson (2007)
Mayo Clin. Proc. 82, 1192-1198
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Endoplasmic reticulum stress and neurodegeneration in rats neonatally infected with borna disease virus..
B. L. Williams and W. I. Lipkin (2006)
J. Virol. 80, 8613-8626
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Kappa opioid control of seizures produced by a virus in an animal model.
M. V. Solbrig, R. Adrian, J. Baratta, J. C. Lauterborn, and G. F. Koob (2006)
Brain 129, 642-654
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CD8 T Cells Require Gamma Interferon To Clear Borna Disease Virus from the Brain and Prevent Immune System-Mediated Neuronal Damage.
J. Hausmann, A. Pagenstecher, K. Baur, K. Richter, H.-J. Rziha, and P. Staeheli (2005)
J. Virol. 79, 13509-13518
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Persistence of Borna Disease Virus in Naturally Infected Sheep.
T. W. Vahlenkamp, A. Konrath, M. Weber, and H. Muller (2002)
J. Virol. 76, 9735-9743
   Abstract »    Full Text »    PDF »
Enhanced Neurovirulence of Borna Disease Virus Variants Associated with Nucleotide Changes in the Glycoprotein and L Polymerase Genes.
Y. Nishino, D. Kobasa, S. A. Rubin, M. V. Pletnikov, and K. M. Carbone (2002)
J. Virol. 76, 8650-8658
   Abstract »    Full Text »    PDF »
1-{beta}-D-Arabinofuranosylcytosine Inhibits Borna Disease Virus Replication and Spread.
J. J. Bajramovic, S. Syan, M. Brahic, J. C. de la Torre, and D. Gonzalez-Dunia (2002)
J. Virol. 76, 6268-6276
   Abstract »    Full Text »    PDF »
Varied Persistent Life Cycles of Borna Disease Virus in a Human Oligodendroglioma Cell Line.
M. S. Ibrahim, M. Watanabe, J. A. Palacios, W. Kamitani, S. Komoto, T. Kobayashi, K. Tomonaga, and K. Ikuta (2002)
J. Virol. 76, 3873-3880
   Abstract »    Full Text »    PDF »
CD8+ T Lymphocytes Mediate Borna Disease Virus-Induced Immunopathology Independently of Perforin.
J. Hausmann, K. Schamel, and P. Staeheli (2001)
J. Virol. 75, 10460-10466
   Abstract »    Full Text »    PDF »
Identification of the Immunodominant H-2Kk-Restricted Cytotoxic T-Cell Epitope in the Borna Disease Virus Nucleoprotein.
K. Schamel, P. Staeheli, and J. Hausmann (2001)
J. Virol. 75, 8579-8588
   Abstract »    Full Text »    PDF »
Borna Disease Virus Phosphoprotein Binds a Neurite Outgrowth Factor, Amphoterin/HMG-1.
W. Kamitani, Y. Shoya, T. Kobayashi, M. Watanabe, B.-J. Lee, G. Zhang, K. Tomonaga, and K. Ikuta (2001)
J. Virol. 75, 8742-8751
   Abstract »    Full Text »    PDF »
Borna Disease Virus and Human Disease.
K. M. Carbone (2001)
Clin. Microbiol. Rev. 14, 513-527
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Immunological and PCR Analyses for Borna Disease Virus in Psychiatric Patients and Blood Donors in Japan.
K. Fukuda, K. Takahashi, Y. Iwata, N. Mori, K. Gonda, T. Ogawa, K. Osonoe, M. Sato, S.-i. Ogata, T. Horimoto, et al. (2001)
J. Clin. Microbiol. 39, 419-429
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Borna Disease Virus Persistence Causes Inhibition of Glutamate Uptake by Feline Primary Cortical Astrocytes.
J.-N. Billaud, C. Ly, T. R. Phillips, and J. C. de la Torre (2000)
J. Virol. 74, 10438-10446
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Isolation of Borna Disease Virus from Human Brain Tissue.
Y. Nakamura, H. Takahashi, Y. Shoya, T. Nakaya, M. Watanabe, K. Tomonaga, K. Iwahashi, K. Ameno, N. Momiyama, H. Taniyama, et al. (2000)
J. Virol. 74, 4601-4611
   Abstract »    Full Text »
Synaptic Pathology in Borna Disease Virus Persistent Infection.
D. Gonzalez-Dunia, M. Watanabe, S. Syan, M. Mallory, E. Masliah, and J. Carlos de la Torre (2000)
J. Virol. 74, 3441-3448
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Inhibition of Borna Disease Virus Replication by Ribavirin.
I. Jordan, T. Briese, D. R. Averett, and W. I. Lipkin (1999)
J. Virol. 73, 7903-7906
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T cell ignorance in mice to Borna disease virus can be overcome by peripheral expression of the viral nucleoprotein.
J. Hausmann, W. Hallensleben, J. C. de la Torre, A. Pagenstecher, C. Zimmermann, H. Pircher, and P. Staeheli (1999)
PNAS 96, 9769-9774
   Abstract »    Full Text »    PDF »
Effect of Immune Priming on Borna Disease.
A. J. Lewis, J. L. Whitton, C. G. Hatalski, H. Weissenböck, and W. I. Lipkin (1999)
J. Virol. 73, 2541-2546
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Borna Disease Virus Nucleoprotein (p40) Is a Major Target for CD8+-T-Cell-Mediated Immune Response.
O. Planz and L. Stitz (1999)
J. Virol. 73, 1715-1718
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Detection and Sequence Analysis of Borna Disease Virus p24 RNA from Peripheral Blood Mononuclear Cells of Patients with Mood Disorders or Schizophrenia and of Blood Donors.
Y. Iwata, K. Takahashi, X. Peng, K. Fukuda, K. Ohno, T. Ogawa, K. Gonda, N. Mori, S.-i. Niwa, and S. Shigeta (1998)
J. Virol. 72, 10044-10049
   Abstract »    Full Text »    PDF »
Borna Disease Virus-Induced Neurological Disorder in Mice: Infection of Neonates Results in Immunopathology.
W. Hallensleben, M. Schwemmle, J. Hausmann, L. Stitz, B. Volk, A. Pagenstecher, and P. Staeheli (1998)
J. Virol. 72, 4379-4386
   Abstract »    Full Text »    PDF »
Virus-Specific CD4+ T Cells Eliminate Borna Disease Virus from the Brain via Induction of Cytotoxic CD8+ T Cells.
K. Noske, T. Bilzer, O. Planz, and L. Stitz (1998)
J. Virol. 72, 4387-4395
   Abstract »    Full Text »    PDF »
Interactions of the Borna Disease Virus P, N, and X Proteins and Their Functional Implications.
M. Schwemmle, M. Salvatore, L. Shi, J. Richt, C. H. Lee, and W. I. Lipkin (1998)
J. Biol. Chem. 273, 9007-9012
   Abstract »    Full Text »    PDF »
A borna virus cDNA encoding a protein recognized by antibodies in humans with behavioral diseases.
S VandeWoude, J. Richt, M. Zink, R Rott, O Narayan, and J. Clements (1990)
Science 250, 1278-1281
   Abstract »    PDF »
Borna Disease Virus: A Possible Etiologic Factor in Human Affective Disorders?.
J. D. Amsterdam, A. Winokur, W. Dyson, S. Herzog, F. Gonzalez, R. Rott, and H. Koprowski (1985)
Arch Gen Psychiatry 42, 1093-1096
   Abstract »    PDF »
Detection of serum antibodies to Borna disease virus in patients with psychiatric disorders.
R Rott, S Herzog, B Fleischer, A Winokur, J Amsterdam, W Dyson, and H Koprowski (1985)
Science 228, 755-756
   Abstract »    PDF »
Borna Disease Virus Persistent Infection Activates Mitogen-activated Protein Kinase and Blocks Neuronal Differentiation of PC12 Cells.
A. Hans, S. Syan, C. Crosio, P. Sassone-Corsi, M. Brahic, and D. Gonzalez-Dunia (2001)
J. Biol. Chem. 276, 7258-7265
   Abstract »    Full Text »    PDF »


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