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Science 24 June 1983:
Vol. 220. no. 4604, pp. 1396 - 1398
DOI: 10.1126/science.6304878
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Articles

Science, Vol 220, Issue 4604, 1396-1398
Copyright © 1983 by American Association for the Advancement of Science

articles

Simple repeat array in Epstein-Barr virus DNA encodes part of the Epstein-Barr nuclear antigen

K Hennessy, M Heller, V van Santen, and E Kieff

The size of the Epstein-Barr virus (EBV) nuclear antigen (EBNA) in cells infected with different EBV isolates varies directly with the size of the EBV triplet repeat array, IR3. The isolate with the largest IR3 fragment has approximately 170 more codons than the isolates with the smallest IR3 fragment; it encodes an EBNA which is approximately 17,000 daltons larger than the smallest EBNA. The EBV IR3 encodes part of a 2-kilobase exon of a latently infected cell messenger RNA which must be translated into a repetitive amino acid domain of EBNA.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Epstein-Barr Virus and Cancer.
M. P. Thompson and R. Kurzrock (2004)
Clin. Cancer Res. 10, 803-821
   Abstract »    Full Text »    PDF »
Expression of the human CFTR gene from episomal oriP-EBNA1-YACs in mouse cells.
D. Huertas, S. Howe, A. McGuigan, and C. Huxley (2000)
Hum. Mol. Genet. 9, 617-629
   Abstract »    Full Text »    PDF »
A second nuclear protein is encoded by Epstein-Barr virus in latent infection.
K Hennessy and E Kieff (1985)
Science 227, 1238-1240
   Abstract »    PDF »


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