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Science 24 June 1983:
Vol. 220. no. 4604, pp. 1389 - 1391
DOI: 10.1126/science.6222474
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Articles

Science, Vol 220, Issue 4604, 1389-1391
Copyright © 1983 by American Association for the Advancement of Science

articles

Suppressor T cell action inhibits the expression of an excluded immunoglobulin gene

TG Parslow, GL Milburn, RG Lynch, and DK Granner

Cells of the murine plasmacytoid line MOPC-315 synthesize two distinct immunoglobulin light chains: a normal lambda II protein, which is incorporated into secretory and surface-bound immunoglobulin, and a truncated, nonfunctional lambda I protein found only in the cytoplasm. Idiotype-specific suppressor T lymphocytes selectively inhibit the expression of both lambda II- and lambda I-specific messenger RNA by MOPC-315 cells. This finding demonstrates that phenotypically excluded light chain genes can be subject to immunoregulatory control and suggests that the expression of divergent lambda isotypes may be coordinately regulated in immunoglobulin-secreting cells.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The immunoglobulin octanucleotide: independent activity and selective interaction with enhancers.
T. Parslow, S. Jones, B Bond, and K. Yamamoto (1987)
Science 235, 1498-1501
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