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Science 17 June 1983:
Vol. 220. no. 4603, pp. 1295 - 1296
DOI: 10.1126/science.6190228
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Articles

Science, Vol 220, Issue 4603, 1295-1296
Copyright © 1983 by American Association for the Advancement of Science

articles

Erythrocyte and brain forms of spectrin in cerebellum: distinct membrane-cytoskeletal domains in neurons

E Lazarides and WJ Nelson

Chicken cerebellum expresses a polypeptide antigenically and biochemically related to the alpha subunit of spectrin, an erythrocyte membrane-cytoskeletal protein. Most of this polypeptide is associated with a brain specific spectrin subunit, gamma-spectrin, and is localized in virtually all neuronal cell bodies and processes. Cerebellum also expresses polypeptides antigenically related to the beta subunits of erythrocyte spectrin and these are also found in association with cerebellar alpha-spectrin but are confined to the plasmalemma of the neuronal cell bodies. This suggests that there is a mechanism for segregating different spectrin complexes into distinct membrane domains within a single cell.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)