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Science 17 June 1983:
Vol. 220. no. 4603, pp. 1281 - 1283
DOI: 10.1126/science.6574602
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Articles

Science, Vol 220, Issue 4603, 1281-1283
Copyright © 1983 by American Association for the Advancement of Science

articles

Transcriptional regulation of globin gene expression in the human erythroid cell line K562

P Charnay and T Maniatis

The effect of hemin on the rate of synthesis and the level of globin messenger RNA's in the human erythroid cell line K562 was examined by means of cloned hybridization probes specific for each of the human embryonic, fetal, and adult globin genes. Hemin increases both the rate of transcription and the level of accumulation of zeta-, epsilon-, gamma-, and alpha-globin messenger RNA's by a factor of 3 to 5. Thus, hemin induction of globin gene expression in K562 cells is at the level of transcription.


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Heme Positively Regulates the Expression of {beta}-Globin at the Locus Control Region via the Transcriptional Factor Bach1 in Erythroid Cells.
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Heme regulates the dynamic exchange of Bach1 and NF-E2-related factors in the Maf transcription factor network.
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Differentiation lineage-specific expression of human heat shock transcription factor 2.
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Physical and Functional Association of Cortactin with Syk in Human Leukemic Cell Line K562.
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In Vivo Binding of Trimethylpsoralen Detects DNA Structural Alterations Associated with Transcribing Regions in the Human beta-Globin Cluster.
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Organization of the alpha-Globin Promoter and Possible Role of Nuclear Factor I in an alpha-Globin-inducible and in a Noninducible Cell Line.
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