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Science 17 June 1983:
Vol. 220. no. 4603, pp. 1277 - 1279
DOI: 10.1126/science.6857247
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Articles

Science, Vol 220, Issue 4603, 1277-1279
Copyright © 1983 by American Association for the Advancement of Science

articles

Mutations affecting programmed cell deaths in the nematode Caenorhabditis elegans

EM Hedgecock, JE Sulston, and JN Thomson

Mutations in two nonessential genes specifically block the phagocytosis of cells programmed to die during development. With few exceptions, these cells still die, suggesting that, in nematodes, engulfment is not necessary for most programmed deaths. Instead, these deaths appear to occur by cell suicide.


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