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Science 10 June 1983:
Vol. 220. no. 4602, pp. 1181 - 1183
DOI: 10.1126/science.6602378
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Articles

Science, Vol 220, Issue 4602, 1181-1183
Copyright © 1983 by American Association for the Advancement of Science

articles

Clot-selective coronary thrombolysis with tissue-type plasminogen activator

Bergmann SR, KA Fox, MM Ter-Pogossian, BE Sobel, and D Collen

Coronary thrombolysis, an intervention that can abort the sequelae of acute myocardial infarction, was accomplished within 10 minutes in dogs by intravenous administration of clot-selective, tissue-type plasminogen activator. In addition to inducing clot lysis, this promising fibrinolytic agent restored intermediary metabolism and nutritional myocardial blood flow, detectable noninvasively with positron tomography, without inducing a systemic fibrinolytic state.


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Intracerebral Hemorrhage Complicating Intravenous Tissue Plasminogen Activator Treatment.
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