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Science 10 June 1983:
Vol. 220. no. 4602, pp. 1177 - 1179
DOI: 10.1126/science.6857242
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Articles

Science, Vol 220, Issue 4602, 1177-1179
Copyright © 1983 by American Association for the Advancement of Science

articles

Hyaluronate in vasculogenesis

RN Feinberg and DC Beebe

Limb buds of chicken embryos contain within the peripheral mesoderm an avascular zone that is rich in hyaluronic acid. Epithelial tissues that synthesize large amounts of hyaluronic acid relative to other glycosaminoglycans caused avascularity when implanted into normally vascular wing mesoderm. Epithelia that synthesize little hyaluronic acid did not cause avascularity. Elvax implants containing hyaluronic acid caused the formation of avascular zones, whereas similar implants containing other glycosaminoglycans did not give rise to avascular zones. Hyaluronic acid may thus play a role in determining the location of blood vessels in the embryo.


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Angiogenesis induced by degradation products of hyaluronic acid.
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