Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 10 June 1983:
Vol. 220. no. 4602, pp. 1125 - 1129
DOI: 10.1126/science.6344214
Prev | Table of Contents | Next

Articles

Science, Vol 220, Issue 4602, 1125-1129
Copyright © 1983 by American Association for the Advancement of Science

articles

Splice junctions: association with variation in protein structure

CS Craik, WJ Rutter, and R Fletterick

A comparison between eukaryotic gene sequences and protein sequences of homologous enzymes from bacterial and mammalian organisms shows that intron-exon junctions frequently coincide with variable surface loops of the protein structures. The altered surface structures can account for functional differences among the members of a family. Sliding of the intron-exon junctions may constitute one mechanism for generating length polymorphisms and divergent sequences found in protein families. Since intron-exon junctions map to protein surfaces, the alterations mediated by sliding of these junctions can be effected without disrupting the stability of the protein core.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
From the Cover: Alternative splicing: A missing piece in the puzzle of intron gain.
R. Tarrio, F. J. Ayala, and F. Rodriguez-Trelles (2008)
PNAS 105, 7223-7228
   Abstract »    Full Text »    PDF »
A Sequence-Based Model Accounts Largely for the Relationship of Intron Positions to Protein Structural Features.
D. W. De Kee, V. Gopalan, and A. Stoltzfus (2007)
Mol. Biol. Evol. 24, 2158-2168
   Abstract »    Full Text »    PDF »
The Evolutionary Gain of Spliceosomal Introns: Sequence and Phase Preferences.
W.-G. Qiu, N. Schisler, and A. Stoltzfus (2004)
Mol. Biol. Evol. 21, 1252-1263
   Abstract »    Full Text »    PDF »
Data-Mining Approaches Reveal Hidden Families of Proteases in the Genome of Malaria Parasite.
Y. Wu, X. Wang, X. Liu, and Y. Wang (2003)
Genome Res. 13, 601-616
   Abstract »    Full Text »    PDF »
Intron evolution as a population-genetic process.
M. Lynch (2002)
PNAS 99, 6118-6123
   Abstract »    Full Text »    PDF »
Testisin, a New Human Serine Proteinase Expressed by Premeiotic Testicular Germ Cells and Lost in Testicular Germ Cell Tumors.
J. D. Hooper, D. L. Nicol, J. L. Dickinson, H. J. Eyre, A. L. Scarman, J. F. Normyle, M. A. Stuttgen, M. L. Douglas, K. A. Lakoski Loveland, G. R. Sutherland, et al. (1999)
Cancer Res. 59, 3199-3205
   Abstract »    Full Text »    PDF »
Molecular Enzymology of Mammalian Delta 1-Pyrroline-5-carboxylate Synthase. ALTERNATIVE SPLICE DONOR UTILIZATION GENERATES ISOFORMS WITH DIFFERENT SENSITIVITY TO ORNITHINE INHIBITION.
C.-a. A. Hu, W.-W. Lin, C. Obie, and D. Valle (1999)
J. Biol. Chem. 274, 6754-6762
   Abstract »    Full Text »    PDF »
Intron "sliding" and the diversity of intron positions.
A. Stoltzfus, J. M. Logsdon Jr., J. D. Palmer, and W. F. Doolittle (1997)
PNAS 94, 10739-10744
   Abstract »    Full Text »    PDF »
Substrate Recognition by Recombinant Serine Collagenase 1 from Uca pugilator.
C. A. Tsu and C. S. Craik (1996)
J. Biol. Chem. 271, 11563-11570
   Abstract »    Full Text »    PDF »
Testing the exon theory of genes: the evidence from protein structure.
A Stoltzfus, D. Spencer, M Zuker, J. Logsdon Jr, and W. Doolittle (1994)
Science 265, 202-207
   Abstract »    PDF »
Genomic organization and deduced amino acid sequence of a putative sodium channel gene in Drosophila.
L Salkoff, A Butler, A Wei, N Scavarda, K Giffen, C Ifune, R Goodman, and G Mandel (1987)
Science 237, 744-749
   Abstract »    PDF »
Atomic structure of thymidylate synthase: target for rational drug design.
L. Hardy, J. Finer-Moore, W. Montfort, M. Jones, D. Santi, and R. Stroud (1987)
Science 235, 448-455
   Abstract »    PDF »
What Introns Have to Tell Us: Hierarchy in Genome Evolution.
W.F. Doolittle (1987)
Cold Spring Harb Symp Quant Biol 52, 907-913
   Abstract »    PDF »
Exon and Domain Evolution in the Proenzymes of Blood Coagulation and Fibrinolysis.
C.C.F. Blake, K. Harlos, and S.K. Holland (1987)
Cold Spring Harb Symp Quant Biol 52, 925-931
   Abstract »    PDF »
The unusual varl gene of yeast mitochondrial DNA.
R. Butow, P. Perlman, and L. Grossman (1985)
Science 228, 1496-1501
   Abstract »    PDF »
Cassette of eight exons shared by genes for LDL receptor and EGF precursor.
T. Sudhof, D. Russell, J. Goldstein, M. Brown, R Sanchez-Pescador, and G. Bell (1985)
Science 228, 893-895
   Abstract »    PDF »
Sequence of the human somatostatin I gene.
L. Shen and W. Rutter (1984)
Science 224, 168-171
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)