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Science 3 June 1983:
Vol. 220. no. 4601, pp. 1073 - 1074
DOI: 10.1126/science.6302846
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Articles

Science, Vol 220, Issue 4601, 1073-1074
Copyright © 1983 by American Association for the Advancement of Science

articles

Ionizing radiation decreases veratridine-stimulated uptake of sodium in rat brain synaptosomes

HN Wixon and WA Hunt

Veratridine-stimulated uptake of sodium-22 in brain synaptosomes was significantly reduced by ionizing radiation over a dose range of 10 to 1000 rads. The response was dose-dependent and involved a decrease in the maximum effect of veratridine on uptake. The central nervous system may be more sensitive to ionizing radiation than generally thought, perhaps through a loss of the ability of the sodium channel to respond properly to stimulation.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)