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Science 3 June 1983:
Vol. 220. no. 4601, pp. 1069 - 1071
DOI: 10.1126/science.6302845
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Articles

Science, Vol 220, Issue 4601, 1069-1071
Copyright © 1983 by American Association for the Advancement of Science

articles

Identity of HeLa cell determinants acquired by vesicular stomatitis virus with a tumor antigen

LM Little, J Zavada, CJ Der, and AS Huang

Growth of vesicular stomatitis virus (VSV) in HeLa cells results in progeny containing non-VSV antigens with a molecular weight around 75,000. The non-VSV antigens were detected by antiserums to HeLa cell determinants. These antiserums precipitate whole virions but do not neutralize them. Because one of the antiserums is directed to a tumor-specific surface antigen of HeLa cells, it appears that VSV specifically acquires such antigens during its passage through human tumor cells.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Lipid Rafts and Pseudotyping.
W. F. Pickl, F. X. Pimentel-Muinos, and B. Seed (2001)
J. Virol. 75, 7175-7183
   Abstract »    Full Text »


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