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Science 3 June 1983: Vol. 220. no. 4601, pp. 1059 - 1061 DOI: 10.1126/science.6844926
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Articles
Science, Vol 220, Issue 4601, 1059-1061
Copyright © 1983 by American Association for the Advancement of Science
Neural crest cells contribute to normal aorticopulmonary septation
ML Kirby,
TF Gale,
and
DE Stewart
By analyzing the hearts of quail-chick chimeras, it was found that neural crest cells at the level of occipital somites 1 to 3 migrate to the region of the aorticopulmonary septum. Bilateral removal of this neural crest population prior to migration causes malformation of the aorticopulmonary septum resulting in common arterial outflow channels or transposition of the great vessels.
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