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Science 27 May 1983:
Vol. 220. no. 4600, pp. 974 - 977
DOI: 10.1126/science.6133351
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Articles

Science, Vol 220, Issue 4600, 974-977
Copyright © 1983 by American Association for the Advancement of Science

articles

Dopamine-beta-hydroxylase activity and homovanillic acid in spinal fluid of schizophrenics with brain atrophy

DP van Kammen, LS Mann, DE Sternberg, M Scheinin, PT Ninan, Marder SR, WB van Kammen, RO Rieder, and M Linnoila

Schizophrenic patients with high ventricle brain ratios and cortical brain atrophy, as shown by computerized tomography, had decreased spinal fluid concentrations of homovanillic acid and dopamine-beta-hydroxylase activity. These decreased cerebral spinal fluid concentrations in patients with brain atrophy support the proposal of disturbed noradrenaline and dopamine neurotransmission in a subgroup of schizophrenic patients.


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Preliminary Evidence of Reduced Combined Output of Dopamine and Its Metabolites in Chronic Schizophrenia.
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Dopamine Metabolism in the Cerebrospinal Fluid of Drug-Free Schizophrenic Patients With and Without Cortical Atrophy.
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Atrophy Limited to the Third Ventricle in Chronic Schizophrenic Patients: Report of a Controlled Series.
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