Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 27 May 1983:
Vol. 220. no. 4600, pp. 967 - 969
DOI: 10.1126/science.6302841
Prev | Table of Contents | Next

Articles

Science, Vol 220, Issue 4600, 967-969
Copyright © 1983 by American Association for the Advancement of Science

articles

Adenosine receptors: autoradiographic evidence for their location on axon terminals of excitatory neurons

RR Goodman, MJ Kuhar, L Hester, and SH Snyder

Adenosine receptors were made visible on light microscopy by autoradiography with tritiated cyclohexyladenosine. In the cerebellum, adenosine receptors were absent in Weaver mice, which lack granule cells, and were displaced in Reeler mice, which have displacements of granule cells. Thus, adenosine receptors appear to be located on the axon terminals of excitatory granule cells in the cerebellum. Removal of one eye of a rat depleted adenosine receptors in the contralateral superior colliculus, suggesting that the receptors occur on axon terminals of excitatory projections from retinal ganglion cells. The presence of adenosine receptors on excitatory axon terminals may explain synaptic inhibition by adenosine and the behavioral effects of xanthines.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Long-Term Administration of {Delta}9-Tetrahydrocannabinol Desensitizes CB1-, Adenosine A1-, and GABAB-Mediated Inhibition of Adenylyl Cyclase in Mouse Cerebellum.
D. E. Selley, M. P. Cassidy, B. R. Martin, and L. J. Sim-Selley (2004)
Mol. Pharmacol. 66, 1275-1284
   Abstract »    Full Text »    PDF »
PET Imaging of Adenosine A1 Receptors with 11C-MPDX as an Indicator of Severe Cerebral Ischemic Insult.
T. Nariai, Y. Shimada, K. Ishiwata, T. Nagaoka, J. Shimada, T. Kuroiwa, K.-I. Ono, K. Ohno, K. Hirakawa, and M. Senda (2003)
J. Nucl. Med. 44, 1839-1844
   Abstract »    Full Text »    PDF »
Adenosine A1 and Class II Metabotropic Glutamate Receptors Mediate Shared Presynaptic Inhibition of Retinotectal Transmission.
C. Zhang and J. T. Schmidt (1999)
J Neurophysiol 82, 2947-2955
   Abstract »    Full Text »    PDF »
Adenosine A1 Receptors Mediate Retinotectal Presynaptic Inhibition: Uncoupling by C-Kinase and Role in LTP During Regeneration.
C. Zhang and J. T. Schmidt (1998)
J Neurophysiol 79, 501-510
   Abstract »    Full Text »    PDF »
Adenosine Modulates N-Methyl-D-Aspartate–Stimulated Hippocampal Nitric Oxide Production In Vivo.
A. Bhardwaj, F. J. Northington, R. C. Koehler, T. Stiefel, D. F. Hanley, and R. J. Traystman (1995)
Stroke 26, 1627-1633
   Abstract »    Full Text »
Input-specific induction of cerebellar long-term depression does not require presynaptic alteration..
D J Linden (1994)
Learn. Mem. 1, 121-128
   Abstract »    PDF »
The Role of Glutamate in Neurotransmission and in Neurologic Disease.
J. T. Greenamyre (1986)
Arch Neurol 43, 1058-1063
   Abstract »    PDF »
Increased Anxiogenic Effects of Caffeine in Panic Disorders.
D. S. Charney, G. R. Heninger, and P. I. Jatlow (1985)
Arch Gen Psychiatry 42, 233-243
   Abstract »    PDF »
Drug and neurotransmitter receptors in the brain.
S. Snyder (1984)
Science 224, 22-31
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)