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Science 27 May 1983:
Vol. 220. no. 4600, pp. 963 - 965
DOI: 10.1126/science.6844921
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Articles

Science, Vol 220, Issue 4600, 963-965
Copyright © 1983 by American Association for the Advancement of Science

articles

Human platelet-derived growth factor (PDGF): amino-terminal amino acid sequence

HN Antoniades and MW Hunkapiller

Human platelet-derived growth factor (PDGF) obtained from outdated human platelets was subjected to amino-terminal amino acid sequence analysis by automated Edman degradation. Despite the apparent presence of limited proteolytic degradation of the protein derived from this method, the sequence analysis reveals two primary peptide sequences and suggests that active PDGF is composed of two, possibly homologous, peptides linked by a disulfide bond or bonds.


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Detection of c-sis transcripts and synthesis of PDGF-like proteins by human osteosarcoma cells.
D. Graves, A. Owen, R. Barth, P Tempst, A Winoto, L Fors, L. Hood, and H. Antoniades (1984)
Science 226, 972-974
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Detection of high molecular weight forms of platelet-derived growth factor by sequence-specific antisera.
H. Niman, R. Houghten, and D. Bowen-Pope (1984)
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Transforming potential of human c-sis nucleotide sequences encoding platelet-derived growth factor.
S. Josephs, L Ratner, M. Clarke, E. Westin, M. Reitz, and F Wong-Staal (1984)
Science 225, 636-639
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Simian sarcoma virus--transformed cells secrete a mitogen identical to platelet-derived growth factor.
A. Owen, P Pantazis, and H. Antoniades (1984)
Science 225, 54-56
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Human-proto-oncogene nucleotide sequences corresponding to the transforming region of simian sarcoma virus.
S. Josephs, C Guo, L Ratner, and F Wong-Staal (1984)
Science 223, 487-491
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Expression of a platelet-derived growth factor-like protein in simian sarcoma virus transformed cells.
T. Deuel, J. Huang, S. Huang, P Stroobant, and M. Waterfield (1983)
Science 221, 1348-1350
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Onc gene related to growth factor gene.
J. Marx (1983)
Science 221, 248
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Simian sarcoma virus onc gene, v-sis, is derived from the gene (or genes) encoding a platelet-derived growth factor.
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