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Science Signaling - Call For Papers

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Science 27 May 1983:
Vol. 220. no. 4600, pp. 919 - 924
DOI: 10.1126/science.6573776
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Articles

Science, Vol 220, Issue 4600, 919-924
Copyright © 1983 by American Association for the Advancement of Science

articles

Somatic cell genetics and gene families

P D'Eustachio and FH Ruddle

The utility of somatic cell genetic analysis for the chromosomal localization of genes in mammals is well established. With the development of recombinant DNA probes and efficient blotting techniques that allow visualization of single-copy cellular genes, somatic cell genetics has been extended from the level of phenotypes expressed by whole cells to the level of the cellular genome itself. This extension has proved invaluable for the analysis of genes not readily expressed in somatic cell hybrids and for the study of multigene families, especially pseudogenes dispersed in different chromosomes throughout the genome.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)