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Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS)
F Barre-Sinoussi,JC Chermann,F Rey,MT Nugeyre,S Chamaret,J Gruest,C Dauguet,C Axler-Blin,F Vezinet-Brun,C Rouzioux,W Rozenbaum,
and
L Montagnier
A retrovirus belonging to the family of recently discovered human T-cell leukemia viruses (HTLV), but clearly distinct from each previous isolate, has been isolated from a Caucasian patient with signs and symptoms that often precede the acquired immune deficiency syndrome (AIDS). This virus is a typical type-C RNA tumor virus, buds from the cell membrane, prefers magnesium for reverse transcriptase activity, and has an internal antigen (p25) similar to HTLV p24. Antibodies from serum of this patient react with proteins from viruses of the HTLV-I subgroup, but type-specific antisera to HTLV-I do not precipitate proteins of the new isolate. The virus from this patient has been transmitted into cord blood lymphocytes, and the virus produced by these cells is similar to the original isolate. From these studies it is concluded that this virus as well as the previous HTLV isolates belong to a general family of T-lymphotropic retroviruses that are horizontally transmitted in humans and may be involved in several pathological syndromes, including AIDS.
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Human Immunodeficiency Virus Type 1 Subtype Distribution in the Worldwide Epidemic: Pathogenetic and Therapeutic Implications.
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Excellence in sexually transmitted infection (STI) diagnostics: recognition of past successes and strategies for the future.
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Immunotherapeutic relief from persistent infections and amyloid disorders.
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J. Virol.
79, 3139-3145
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Anti-Vpr Activity of a Yeast Chaperone Protein.
Z. Benko, D. Liang, E. Agbottah, J. Hou, K. Chiu, M. Yu, S. Innis, P. Reed, W. Kabat, R. T. Elder, et al. (2004)
J. Virol.
78, 11016-11029
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Where Does HIV Live?.
J. Stebbing, B. Gazzard, and D. C. Douek (2004)
N. Engl. J. Med.
350, 1872-1880
|Full Text »|PDF »
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Z. Si, N. Madani, J. M. Cox, J. J. Chruma, J. C. Klein, A. Schon, N. Phan, L. Wang, A. C. Biorn, S. Cocklin, et al. (2004)
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101, 5036-5041
|Abstract »|Full Text »|PDF »
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M. Giri, K. E. Ugen, and D. B. Weiner (2004)
Clin. Microbiol. Rev.
17, 370-389
|Abstract »|Full Text »|PDF »
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N. Madani, A. L. Perdigoto, K. Srinivasan, J. M. Cox, J. J. Chruma, J. LaLonde, M. Head, A. B. Smith III, and J. G. Sodroski (2004)
J. Virol.
78, 3742-3752
|Abstract »|Full Text »|PDF »
Inhibition of HIV-1 Replication by Cell-penetrating Peptides Binding Rev.
A. Roisin, J.-P. Robin, N. Dereuddre-Bosquet, A.-L. Vitte, D. Dormont, P. Clayette, and P. Jalinot (2004)
J. Biol. Chem.
279, 9208-9214
|Abstract »|Full Text »|PDF »
Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120.
C.-c. Huang, M. Venturi, S. Majeed, M. J. Moore, S. Phogat, M.-Y. Zhang, D. S. Dimitrov, W. A. Hendrickson, J. Robinson, J. Sodroski, et al. (2004)
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101, 2706-2711
|Abstract »|Full Text »|PDF »
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M. Khati, M. Schuman, J. Ibrahim, Q. Sattentau, S. Gordon, and W. James (2003)
J. Virol.
77, 12692-12698
|Abstract »|Full Text »|PDF »
Novel Human Immunodeficiency Virus (HIV) Inhibitors That Have a Dual Mode of Anti-HIV Action.
M. Stevens, C. Pannecouque, E. De Clercq, and J. Balzarini (2003)
Antimicrob. Agents Chemother.
47, 3109-3116
|Abstract »|Full Text »|PDF »
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W. E. Johnson, H. Sanford, L. Schwall, D. R. Burton, P. W. H. I. Parren, J. E. Robinson, and R. C. Desrosiers (2003)
J. Virol.
77, 9993-10003
|Abstract »|Full Text »|PDF »
Inhibition of Human Immunodeficiency Virus by a New Class of Pyridine Oxide Derivatives.
M. Stevens, C. Pannecouque, E. De Clercq, and J. Balzarini (2003)
Antimicrob. Agents Chemother.
47, 2951-2957
|Abstract »|Full Text »|PDF »
Infectious HIV-1 assembles in late endosomes in primary macrophages.
A. Pelchen-Matthews, B. Kramer, and M. Marsh (2003)
J. Cell Biol.
162, 443-455
|Abstract »|Full Text »|PDF »
Characterization of Entry Mechanisms of Human Herpesvirus 8 by Using an Rta-Dependent Reporter Cell Line.
N. Inoue, J. Winter, R. B. Lal, M. K. Offermann, and S. Koyano (2003)
J. Virol.
77, 8147-8152
|Abstract »|Full Text »|PDF »
Cytolysis by CCR5-Using Human Immunodeficiency Virus Type 1 Envelope Glycoproteins Is Dependent on Membrane Fusion and Can Be Inhibited by High Levels of CD4 Expression.
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J. M. Kilby and J. J. Eron (2003)
N. Engl. J. Med.
348, 2228-2238
|Full Text »|PDF »
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L. Zargarian, M. S. Benleumi, J.-G. Renisio, H. Merad, R. G. Maroun, F. Wieber, O. Mauffret, H. Porumb, F. Troalen, and S. Fermandjian (2003)
J. Biol. Chem.
278, 19966-19973
|Abstract »|Full Text »|PDF »
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D. I. Albu, A. Jones-Trower, A. M. Woron, K. Stellrecht, C. C. Broder, and D. W. Metzger (2003)
J. Virol.
77, 5589-5597
|Abstract »|Full Text »|PDF »
New Anti-Human Immunodeficiency Virus Type 1 6-Aminoquinolones: Mechanism of Action.
C. Parolin, B. Gatto, C. Del Vecchio, T. Pecere, E. Tramontano, V. Cecchetti, A. Fravolini, S. Masiero, M. Palumbo, and G. Palu (2003)
Antimicrob. Agents Chemother.
47, 889-896
|Abstract »|Full Text »|PDF »
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B. Dey, C. S. Del Castillo, and E. A. Berger (2003)
J. Virol.
77, 2859-2865
|Abstract »|Full Text »|PDF »
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J. J. Kohler, D. L. Tuttle, C. R. Coberley, J. W. Sleasman, and M. M. Goodenow (2003)
J. Leukoc. Biol.
73, 407-416
|Abstract »|Full Text »|PDF »
CD4 Binding Site Antibodies Inhibit Human Immunodeficiency Virus gp120 Envelope Glycoprotein Interaction with CCR5.
A. Raja, M. Venturi, P. Kwong, and J. Sodroski (2002)
J. Virol.
77, 713-718
|Abstract »|Full Text »|PDF »
Human and Simian Immunodeficiency Virus Capsid Proteins Are Major Viral Determinants of Early, Postentry Replication Blocks in Simian Cells.
C. M. Owens, P. C. Yang, H. Gottlinger, and J. Sodroski (2002)
J. Virol.
77, 726-731
|Abstract »|Full Text »|PDF »
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B. M. Badran, S. M. Wolinsky, A. Burny, and K. E. Willard-Gallo (2002)
J. Biol. Chem.
277, 47136-47148
|Abstract »|Full Text »|PDF »
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A. de Paulis, G. Florio, N. Prevete, M. Triggiani, I. Fiorentino, A. Genovese, and G. Marone (2002)
J. Immunol.
169, 4559-4567
|Abstract »|Full Text »|PDF »
Tat HIV-1 Primary and Tertiary Structures Critical to Immune Response Against Non-homologous Variants.
S. Opi, J.-M. Peloponese Jr., D. Esquieu, G. Campbell, J. de Mareuil, A. Walburger, M. Solomiac, C. Gregoire, E. Bouveret, D. L. Yirrell, et al. (2002)
J. Biol. Chem.
277, 35915-35919
|Abstract »|Full Text »|PDF »
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S.-H. Xiang, P. D. Kwong, R. Gupta, C. D. Rizzuto, D. J. Casper, R. Wyatt, L. Wang, W. A. Hendrickson, M. L. Doyle, and J. Sodroski (2002)
J. Virol.
76, 9888-9899
|Abstract »|Full Text »|PDF »
Blockade of HIV-1 Infection of New World Monkey Cells Occurs Primarily at the Stage of Virus Entry.
J. A. LaBonte, G. J. Babcock, T. Patel, and J. Sodroski (2002)
J. Exp. Med.
196, 431-445
|Abstract »|Full Text »|PDF »
Novel Endogenous Retrovirus in Rabbits Previously Reported as Human Retrovirus 5.
D. J. Griffiths, C. Voisset, P. J. W. Venables, and R. A. Weiss (2002)
J. Virol.
76, 7094-7102
|Abstract »|Full Text »|PDF »
Potency of Nonnucleoside Reverse Transcriptase Inhibitors (NNRTIs) Used in Combination with Other Human Immunodeficiency Virus NNRTIs, NRTIs, or Protease Inhibitors.
R. W. King, R. M. Klabe, C. D. Reid, and S. K. Erickson-Viitanen (2002)
Antimicrob. Agents Chemother.
46, 1640-1646
|Abstract »|Full Text »|PDF »
Human Immunodeficiency Virus and Malignancy: Thoughts on Viral Oncogenesis.
W. P. Schecter (2001)
Arch Surg
136, 1419-1425
|Full Text »|PDF »
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M. Kim, B. Chen, R. E. Hussey, Y. Chishti, D. Montefiori, J. A. Hoxie, O. Byron, G. Campbell, S. C. Harrison, and E. L. Reinherz (2001)
J. Biol. Chem.
276, 42667-42676
|Abstract »|Full Text »|PDF »
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C. W-H. Zhang, Y. Chishti, R. E. Hussey, and E. L. Reinherz (2001)
J. Biol. Chem.
276, 39577-39585
|Abstract »|Full Text »|PDF »
Interleukin-7 and infection itself by human immunodeficiency virus 1 favor virus persistence in mature CD4+CD8{-}CD3+ thymocytes through sustained induction of Bcl-2.
E. Guillemard, M.-T. Nugeyre, L. Chene, N. Schmitt, C. Jacquemot, F. Barre-Sinoussi, and N. Israel (2001)
Blood
98, 2166-2174
|Abstract »|Full Text »|PDF »
CD8+ T cells are an in vivo reservoir for human T-cell lymphotropic virus type I.
M. Nagai, M. B. Brennan, J. A. Sakai, C. A. Mora, and S. Jacobson (2001)
Blood
98, 1858-1861
|Abstract »|Full Text »|PDF »
Inhibition of Human Immunodeficiency Virus Type 1 Transcription by Chemical Cyclin-Dependent Kinase Inhibitors.
D. Wang, C. de la Fuente, L. Deng, L. Wang, I. Zilberman, C. Eadie, M. Healey, D. Stein, T. Denny, L. E. Harrison, et al. (2001)
J. Virol.
75, 7266-7279
|Abstract »|Full Text »|PDF »
Membrane-Fusing Capacity of the Human Immunodeficiency Virus Envelope Proteins Determines the Efficiency of CD4+ T-Cell Depletion in Macaques Infected by a Simian-Human Immunodeficiency Virus.
B. Etemad-Moghadam, D. Rhone, T. Steenbeke, Y. Sun, J. Manola, R. Gelman, J. W. Fanton, P. Racz, K. Tenner-Racz, M. K. Axthelm, et al. (2001)
J. Virol.
75, 5646-5655
|Abstract »|Full Text »
AIDS -- The First 20 Years.
K. A. Sepkowitz (2001)
N. Engl. J. Med.
344, 1764-1772
|Full Text »|PDF »
AIDS -- Past and Future.
M. S. Gottlieb (2001)
N. Engl. J. Med.
344, 1788-1791
|Full Text »|PDF »
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Z. Si, M. Cayabyab, and J. Sodroski (2001)
J. Virol.
75, 4208-4218
|Abstract »|Full Text »
Loss of a Single N-Linked Glycan Allows CD4-Independent Human Immunodeficiency Virus Type 1 Infection by Altering the Position of the gp120 V1/V2 Variable Loops.
P. Kolchinsky, E. Kiprilov, P. Bartley, R. Rubinstein, and J. Sodroski (2001)
J. Virol.
75, 3435-3443
|Abstract »|Full Text »
Increased Neutralization Sensitivity of CD4-Independent Human Immunodeficiency Virus Variants.
P. Kolchinsky, E. Kiprilov, and J. Sodroski (2001)
J. Virol.
75, 2041-2050
|Abstract »|Full Text »
GLI-2 Modulates Retroviral Gene Expression.
M. J. Smith, S. D. Gitlin, C. M. Browning, B. R. Lane, N. M. Clark, N. Shah, S. Rainier, and D. M. Markovitz (2001)
J. Virol.
75, 2301-2313
|Abstract »|Full Text »
A human myeloma cell line suitable for the generation of human monoclonal antibodies.
A. Karpas, A. Dremucheva, and B. H. Czepulkowski (2001)
PNAS
98, 1799-1804
|Abstract »|Full Text »|PDF »
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M. Cayabyab, S. Hinuma, M. Farzan, H. Choe, S. Fukusumi, C. Kitada, N. Nishizawa, M. Hosoya, O. Nishimura, T. Messele, et al. (2000)
J. Virol.
74, 11972-11976
|Abstract »|Full Text »
Tat Protein Is an HIV-1-Encoded {beta}-Chemokine Homolog That Promotes Migration and Up-Regulates CCR3 Expression on Human Fc{epsilon}RI+ Cells.
A. de Paulis, R. De Palma, L. Di Gioia, M. Carfora, N. Prevete, G. Tosi, R. S. Accolla, and G. Marone (2000)
J. Immunol.
165, 7171-7179
|Abstract »|Full Text »|PDF »
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13, 422-425
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J. Virol.
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|Abstract »|Full Text »
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|Abstract »|Full Text »
Polyanionic (i.e., Polysulfonate) Dendrimers Can Inhibit the Replication of Human Immunodeficiency Virus by Interfering with Both Virus Adsorption and Later Steps (Reverse Transcriptase/Integrase) in the Virus Replicative Cycle.
M. Witvrouw, V. Fikkert, W. Pluymers, B. Matthews, K. Mardel, D. Schols, J. Raff, Z. Debyser, E. De Clercq, G. Holan, et al. (2000)
Mol. Pharmacol.
58, 1100-1108
|Abstract »|Full Text »
