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Science 20 May 1983:
Vol. 220. no. 4599, pp. 795 - 798
DOI: 10.1126/science.6687762
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Articles

Science, Vol 220, Issue 4599, 795-798
Copyright © 1983 by American Association for the Advancement of Science

articles

DNA rearrangement and altered RNA expression of the c-myb oncogene in mouse plasmacytoid lymphosarcomas

JF Mushinski, M Potter, Bauer SR, and EP Reddy

Three types of tumors termed plasmacytomas (ABPC's), lymphosarcomas (ABLS's), and plasmacytoid lymphosarcomas (ABPL's) arise in BALB/c mice treated with pristane and Abelson murine leukemia virus (A-MuLV). While most ABPC's and BLS's contain integrated A-MuLV proviral genome and synthesize the v-abl RNA, most ABPL's do not. The ABPL tumors were examined for the expression of other oncogenes that may be associated with their transformed state, in the absence of transforming virus. These tumors expressed abundant c-myb RNA of unusually large size and showed DNA rearrangements of the c-myb locus.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Relationship between the c-myb locus and the 6q-chromosomal aberration in leukemias and lymphomas.
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Activation of the c-myb locus by viral insertional mutagenesis in plasmacytoid lymphosarcomas.
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Cellular oncogenes and multistep carcinogenesis.
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Science. ISSN 0036-8075 (print), 1095-9203 (online)