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Science 13 May 1983:
Vol. 220. no. 4598, pp. 728 - 731
DOI: 10.1126/science.6836310
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Articles

Science, Vol 220, Issue 4598, 728-731
Copyright © 1983 by American Association for the Advancement of Science

articles

Monocyte chemotaxis: stimulation by specific exosite region in thrombin

R Bar-Shavit, A Kahn, GD Wilner, and JW Fenton 2nd

Human alpha-thrombin is a potent chemoattractant for human monocytes, with optimum activity occurring at about 10 nanomoles per liter. A variety of thrombins that were chemically modified to alter procoagulant or esterolytic functions showed a similar optimum activity, but complexes of prothrombin or alpha-thrombin with either antithrombin III or hirudin did not. These findings indicate that the regions in thrombin responsible for monocyte chemotaxis are proximate to those involved in certain protein recognition interactions of alpha-thrombin (for example, hirudin binding) but are distinct from the catalytic site and from certain exosites required for clotting.


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