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Science 6 May 1983:
Vol. 220. no. 4597, pp. 629 - 632
DOI: 10.1126/science.6188216
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Articles

Science, Vol 220, Issue 4597, 629-632
Copyright © 1983 by American Association for the Advancement of Science

articles

Narcolepsy: biogenic amine deficits in an animal model

IN Mefford, TL Baker, R Boehme, AS Foutz, RD Ciaranello, JD Barchas, and WC Dement

Concentrations of biogenic amine metabolites in discrete brain areas differed significantly between dogs with genetically transmitted narcolepsy and age- and breed-matched controls. Dopamine and 3,4-dihydroxyphenylacetic acid were consistently elevated in the brains of narcoleptic animals, while homovanillic acid was not. Narcoleptic animals consistently exhibited lower utilization of dopamine and higher intraneuronal degradation of dopamine but no uniform decrease in serotonin utilization. Hence neuropathology appears to be associated with genetically transmitted canine narcolepsy. The data indicate a nonglobal depression of dopamine utilization or turnover or both.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Neuronal Degeneration in Canine Narcolepsy.
J. M. Siegel, R. Nienhuis, S. Gulyani, S. Ouyang, M. F. Wu, E. Mignot, R. C. Switzer, G. McMurry, and M. Cornford (1999)
J. Neurosci. 19, 248-257
   Abstract »    Full Text »    PDF »
Sleep Disorders: Sleep Apnea and Narcolepsy.
A. KALES, A. VELA-BUENO, and J. D. KALES (1987)
Ann Intern Med 106, 434-443
   Abstract »    PDF »
Dopamine Metabolism in the Cerebrospinal Fluid of Drug-Free Schizophrenic Patients With and Without Cortical Atrophy.
D. P. van Kammen, W. B. van Kammen, L. S. Mann, T. Seppala, and M. Linnoila (1986)
Arch Gen Psychiatry 43, 978-983
   Abstract »    PDF »


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