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Science 6 May 1983:
Vol. 220. no. 4597, pp. 626 - 629
DOI: 10.1126/science.6301013
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Articles

Science, Vol 220, Issue 4597, 626-629
Copyright © 1983 by American Association for the Advancement of Science

articles

Recognition sites for norepinephrine uptake: regulation by neurotransmitter

CM Lee, JA Javitch, and SH Snyder

Recognition sites for the uptake of norepinephrine on adrenergic neurons in the brain and periphery were labeled with [3H]desipramine. The number of these uptake sites varied with the concentration of transmitter; depletion of norepinephrine with reserpine reduced the number of uptake sites, whereas increasing the concentration of norepinephrine induced by treatment with monoamine oxidase inhibitors raised the number of binding sites. These dynamic alterations in norepinephrine uptake recognition sites may regulate synaptic function homeostatically, providing less inactivation of reuptake when the synaptic concentration of the transmitter is low and increased inactivation when it is high.


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