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Science 6 May 1983:
Vol. 220. no. 4597, pp. 617 - 619
DOI: 10.1126/science.6836306
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Articles

Science, Vol 220, Issue 4597, 617-619
Copyright © 1983 by American Association for the Advancement of Science

articles

Endogenous pyrogen activity in human plasma after exercise

JG Cannon and MJ Kluger

Plasma obtained from human subjects after exercise and injected intraperitoneally into rats elevated rat rectal temperature and depressed plasma iron and zinc concentrations. The pyrogenic component was heat-denaturable and had an apparent molecular weight of 14,000 daltons. Human mononuclear leukocytes obtained after exercise and incubated in vitro released a factor into the medium that also elevated body temperature in rats and reduced trace metal concentrations. These results suggest that endogenous pyrogen, a protein mediator of fever and trace metal metabolism during infection, is released during exercise.


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