Science 6 May 1983: Vol. 220. no. 4597, pp. 568 - 575 DOI: 10.1126/science.6301011

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Articles

Leukotriene B4-induced changes in vascular permeability are mediated by neutrophil release of heparin-binding protein (HBP/CAP37/azurocidin).

A. Di Gennaro, E. Kenne, M. Wan, O. Soehnlein, L. Lindbom, and J. Z. Haeggstrom (2009)
FASEB J 23, 1750-1757
 |  Abstract »  |  Full Text »  |  PDF »

Partial Replacement of Dietary (n-6) Fatty Acids with Medium-Chain Triglycerides Decreases the Incidence of Spontaneous Colitis in Interleukin-10-Deficient Mice.

J. Mane, E. Pedrosa, V. Loren, I. Ojanguren, L. Fluvia, E. Cabre, G. Rogler, and M. A. Gassull (2009)
J. Nutr. 139, 603-610
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Induction of CYP4F3 by Benzene Metabolites in Human White Blood Cells in Vivo in Human Promyelocytic Leukemic Cell Lines and ex Vivo in Human Blood Neutrophils.

Z. Zhao, X. He, Y. Bi, Y. Xia, N. Tao, L. Li, and Q. Ma (2009)
Drug Metab. Dispos. 37, 282-291
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Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions.

C. N. Serhan, R. Yang, K. Martinod, K. Kasuga, P. S. Pillai, T. F. Porter, S. F. Oh, and M. Spite (2009)
J. Exp. Med. 206, 15-23
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Up-regulation and Cytoprotective Role of Epithelial Multidrug Resistance-associated Protein 1 in Inflammatory Bowel Disease.

H. Blokzijl, A. van Steenpaal, S. V. Borght, L. I. H. Bok, L. Libbrecht, M. Tamminga, M. Geuken, T. A. D. Roskams, G. Dijkstra, H. Moshage, et al. (2008)
J. Biol. Chem. 283, 35630-35637
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ERK-mediated regulation of leukotriene biosynthesis by androgens: A molecular basis for gender differences in inflammation and asthma.

C. Pergola, G. Dodt, A. Rossi, E. Neunhoeffer, B. Lawrenz, H. Northoff, B. Samuelsson, O. Radmark, L. Sautebin, and O. Werz (2008)
PNAS 105, 19881-19886
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Atherosclerosis: evidence for impairment of resolution of vascular inflammation governed by specific lipid mediators.

A. J. Merched, K. Ko, K. H. Gotlinger, C. N. Serhan, and L. Chan (2008)
FASEB J 22, 3595-3606
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Expression of enzymes and receptors of the leukotriene pathway in human neuroblastoma promotes tumor survival and provides a target for therapy.

B. Sveinbjornsson, A. Rasmuson, N. Baryawno, M. Wan, I. Pettersen, F. Ponthan, A. Orrego, J. Z. Haeggstrom, J. I. Johnsen, and P. Kogner (2008)
FASEB J 22, 3525-3536
 |  Abstract »  |  Full Text »  |  PDF »

Modulation of Lipid and Protein Mediators of Inflammation by Cytosolic Phospholipase A2{alpha} during Experimental Sepsis.

N. Uozumi, Y. Kita, and T. Shimizu (2008)
J. Immunol. 181, 3558-3566
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Promotor Polymorphisms in Leukotriene C4 Synthase and Risk of Ischemic Cerebrovascular Disease.

J. J. Freiberg, A. Tybjaerg-Hansen, H. Sillesen, G. B. Jensen, and B. G. Nordestgaard (2008)
Arterioscler. Thromb. Vasc. Biol. 28, 990-996
 |  Abstract »  |  Full Text »  |  PDF »

Human CMV infection induces 5-lipoxygenase expression and leukotriene B4 production in vascular smooth muscle cells.

H. Qiu, K. Straat, A. Rahbar, M. Wan, C. Soderberg-Naucler, and J. Z. Haeggstrom (2008)
J. Exp. Med. 205, 19-24
 |  Abstract »  |  Full Text »  |  PDF »

NADPH oxidase deficiency results in reduced alveolar macrophage 5-lipoxygenase expression and decreased leukotriene synthesis.

M. J. Coffey, C. H. Serezani, S. M. Phare, N. Flamand, and M. Peters-Golden (2007)
J. Leukoc. Biol. 82, 1585-1591
 |  Abstract »  |  Full Text »  |  PDF »

An Increased Expression of Cysteinyl Leukotriene 2 Receptor in Colorectal Adenocarcinomas Correlates with High Differentiation.

C. Magnusson, R. Ehrnstrom, J. Olsen, and A. Sjolander (2007)
Cancer Res. 67, 9190-9198
 |  Abstract »  |  Full Text »  |  PDF »

Development of a Homogeneous Time-Resolved Fluorescence Leukotriene B4 Assay for Determining the Activity of Leukotriene A4 Hydrolase.

A. M. Liang, E. Claret, J. Ouled-Diaf, A. Jean, D. Vogel, D. R. Light, S. W. Jones, W. J. Guilford, J. F. Parkinson, and R. M. Snider (2007)
J Biomol Screen 12, 536-545
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Association Between A Leukotriene C4 Synthase Gene Promoter Polymorphism and Coronary Artery Calcium in Young Women: The Muscatine Study.

D. M. Iovannisci, E. J. Lammer, L. Steiner, S. Cheng, L. T. Mahoney, P. H. Davis, R. M. Lauer, and T. L. Burns (2007)
Arterioscler. Thromb. Vasc. Biol. 27, 394-399
 |  Abstract »  |  Full Text »  |  PDF »

Prostaglandin F2{alpha}, but Not Latanoprost, Increases the Ca2+ Sensitivity of the Pig Iris Sphincter Muscle.

Y. Hasegawa, J. Nishimura, N. Niiro, K. Hirano, T. Ishibashi, and H. Kanaide (2006)
Invest. Ophthalmol. Vis. Sci. 47, 4865-4871
 |  Abstract »  |  Full Text »  |  PDF »

Thematic review series: Systems Biology Approaches to Metabolic and Cardiovascular Disorders. Lipidomics: a global approach to lipid analysis in biological systems.

A. D. Watson (2006)
J. Lipid Res. 47, 2101-2111
 |  Abstract »  |  Full Text »  |  PDF »

Coactosin-like protein supports 5-lipoxygenase enzyme activity and up-regulates leukotriene A4 production.

M. Rakonjac, L. Fischer, P. Provost, O. Werz, D. Steinhilber, B. Samuelsson, and O. Radmark (2006)
PNAS 103, 13150-13155
 |  Abstract »  |  Full Text »  |  PDF »

Identification and Functional Characterization of the Moss Physcomitrella patens {Delta}5-Desaturase Gene Involved in Arachidonic and Eicosapentaenoic Acid Biosynthesis.

S. Kaewsuwan, E. B. Cahoon, P.-F. Perroud, C. Wiwat, N. Panvisavas, R. S. Quatrano, D. J. Cove, and N. Bunyapraphatsara (2006)
J. Biol. Chem. 281, 21988-21997
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Genetic Variants of Arachidonate 5-Lipoxygenase-Activating Protein, and Risk of Incident Myocardial Infarction and Ischemic Stroke: A Nested Case-Control Approach.

R. Y.L. Zee, S. Cheng, H. H Hegener, H. A. Erlich, and P. M Ridker (2006)
Stroke 37, 2007-2011
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-4 Induces 15-Lipoxygenase-1 Expression in Human Orbital Fibroblasts from Patients with Graves Disease: EVIDENCE FOR ANATOMIC SITE-SELECTIVE ACTIONS OF Th2 CYTOKINES.

B. Chen, S. Tsui, W. E. Boeglin, R. S. Douglas, A. R. Brash, and T. J. Smith (2006)
J. Biol. Chem. 281, 18296-18306
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Expression of 5-lipoxygenase and leukotriene A4 hydrolase in human atherosclerotic lesions correlates with symptoms of plaque instability.

H. Qiu, A. Gabrielsen, H. E. Agardh, M. Wan, A. Wetterholm, C.-H. Wong, U. Hedin, J. Swedenborg, G. K. Hansson, B. Samuelsson, et al. (2006)
PNAS 103, 8161-8166
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Differential induction of BLT receptor expression on human endothelial cells by lipopolysacharide, cytokines, and leukotriene B4.

H. Qiu, A.-S. Johansson, M. Sjostrom, M. Wan, O. Schroder, J. Palmblad, and J. Z. Haeggstrom (2006)
PNAS 103, 6913-6918
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Cysteinyl leukotriene 2 receptor and protease-activated receptor 1 activate strongly correlated early genes in human endothelial cells.

B. Uzonyi, K. Lotzer, S. Jahn, C. Kramer, M. Hildner, E. Bretschneider, D. Radke, M. Beer, R. Vollandt, J. F. Evans, et al. (2006)
PNAS 103, 6326-6331
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Binding Investigation of Human 5-Lipoxygenase with Its Inhibitors by SPR Technology Correlating with Molecular Docking Simulation..

L. Du, Z. Zhang, X. Luo, K. Chen, X. Shen, and H. Jiang (2006)
J. Biochem. 139, 715-723
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The Inflammatory Mediator Leukotriene D4 Induces beta-Catenin Signaling and Its Association with Antiapoptotic Bcl-2 in Intestinal Epithelial Cells.

M. Mezhybovska, K. Wikstrom, J. F. Ohd, and A. Sjolander (2006)
J. Biol. Chem. 281, 6776-6784
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CysLT1 receptor is a target for extracellular nucleotide-induced heterologous desensitization: a possible feedback mechanism in inflammation.

V. Capra, S. Ravasi, M. R. Accomazzo, S. Citro, M. Grimoldi, M. P. Abbracchio, and G. E. Rovati (2005)
J. Cell Sci. 118, 5625-5636
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Up-regulation of prostaglandin biosynthesis by leukotriene C4 in elicited mice peritoneal macrophages activated with lipopolysaccharide/interferon-{gamma}.

A. Rossi, A. M. Acquaviva, F. Iuliano, R. Di Paola, S. Cuzzocrea, and L. Sautebin (2005)
J. Leukoc. Biol. 78, 985-991
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Leukotriene A4 Hydrolase, Insights into the Molecular Evolution by Homology Modeling and Mutational Analysis of Enzyme from Saccharomyces cerevisiae.

F. Tholander, F. Kull, E. Ohlson, J. Shafqat, M. M. G. M. Thunnissen, and J. Z. Haeggstrom (2005)
J. Biol. Chem. 280, 33477-33486
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Leukotrienes Play a Role in the Control of Parasite Burden in Murine Strongyloidiasis.

E. R. Machado, M. T. Ueta, E. V. Lourenco, F. F. Anibal, C. A. Sorgi, E. G. Soares, M. C. Roque-Barreira, A. I. Medeiros, and L. H. Faccioli (2005)
J. Immunol. 175, 3892-3899
 |  Abstract »  |  Full Text »  |  PDF »

Caspase-mediated degradation of human 5-lipoxygenase in B lymphocytic cells.

O. Werz, I. Tretiakova, A. Michel, A. Ulke-Lemee, M. Hornig, L. Franke, G. Schneider, B. Samuelsson, O. Radmark, and D. Steinhilber (2005)
PNAS 102, 13164-13169
 |  Abstract »  |  Full Text »  |  PDF »

Gas gangrene: an open and closed case.

R. W. Titball (2005)
Microbiology 151, 2821-2828
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Inhibition of Atherogenesis in BLT1-Deficient Mice Reveals a Role for LTB4 and BLT1 in Smooth Muscle Cell Recruitment.

E. A. Heller, E. Liu, A. M. Tager, S. Sinha, J. D. Roberts, S. L. Koehn, P. Libby, E. R. Aikawa, J. Q. Chen, P. Huang, et al. (2005)
Circulation 112, 578-586
 |  Abstract »  |  Full Text »  |  PDF »

Increased Susceptibility to Pulmonary Hypertension in Heterozygous BMPR2-Mutant Mice.

Y. Song, J. E. Jones, H. Beppu, J. F. Keaney Jr, J. Loscalzo, and Y.-Y. Zhang (2005)
Circulation 112, 553-562
 |  Abstract »  |  Full Text »  |  PDF »

Pro- and anti-inflammatory substances modulate expression of the leukotriene B4 receptor, BLT1, in human monocytes.

A. Pettersson, A. Sabirsh, J. Bristulf, K. Kidd-Ljunggren, B. Ljungberg, C. Owman, and U. Karlsson (2005)
J. Leukoc. Biol. 77, 1018-1025
 |  Abstract »  |  Full Text »  |  PDF »

Contribution of Arachidonic Acid Metabolites Derived Via Cytochrome P4504A to Angiotensin II-Induced Neointimal Growth.

F. A. Yaghini, C. Zhang, J.-H. Parmentier, A. M. Estes, N. Jafari, S. A. Schaefer, and K. U. Malik (2005)
Hypertension 45, 1182-1187
 |  Abstract »  |  Full Text »  |  PDF »

Effects of a 5-Lipoxygenase-Activating Protein Inhibitor on Biomarkers Associated With Risk of Myocardial Infarction: A Randomized Trial.

H. Hakonarson, S. Thorvaldsson, A. Helgadottir, D. Gudbjartsson, F. Zink, M. Andresdottir, A. Manolescu, D. O. Arnar, K. Andersen, A. Sigurdsson, et al. (2005)
JAMA 293, 2245-2256
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C. Feisst, D. Albert, D. Steinhilber, and O. Werz (2005)
Mol. Pharmacol. 67, 1751-1757
 |  Abstract »  |  Full Text »  |  PDF »

Cysteinyl Leukotrienes in Allergic Inflammation: Strategic Target for Therapy.

W. Busse and M. Kraft (2005)
Chest 127, 1312-1326
 |  Abstract »  |  Full Text »  |  PDF »

ALOX5AP Gene and the PDE4D Gene in a Central European Population of Stroke Patients.

E. Lohmussaar, A. Gschwendtner, J. C. Mueller, T. Org, E. Wichmann, G. Hamann, T. Meitinger, and M. Dichgans (2005)
Stroke 36, 731-736
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Cysteinyl Leukotriene Type 1 Receptor Internalization and Signaling.

S. Naik, C. K. Billington, R. M. Pascual, D. A. Deshpande, F. P. Stefano, T. A. Kohout, D. M. Eckman, J. L. Benovic, and R. B. Penn (2005)
J. Biol. Chem. 280, 8722-8732
 |  Abstract »  |  Full Text »  |  PDF »

Leukotriene A4 Hydrolase/Aminopeptidase, the Gatekeeper of Chemotactic Leukotriene B4 Biosynthesis.

J. Z. Haeggstrom (2004)
J. Biol. Chem. 279, 50639-50642
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Directed Vascular Expression of Human Cysteinyl Leukotriene 2 Receptor Modulates Endothelial Permeability and Systemic Blood Pressure.

Y. Hui, Y. Cheng, I. Smalera, W. Jian, L. Goldhahn, G. A. FitzGerald, and C. D. Funk (2004)
Circulation 110, 3360-3366
 |  Abstract »  |  Full Text »  |  PDF »

Reduction of the multiple organ injury and dysfunction caused by endotoxemia in 5-lipoxygenase knockout mice and by the 5-lipoxygenase inhibitor zileuton.

M. Collin, A. Rossi, S. Cuzzocrea, N. S. A. Patel, R. Di Paola, J. Hadley, M. Collino, L. Sautebin, and C. Thiemermann (2004)
J. Leukoc. Biol. 76, 961-970
 |  Abstract »  |  Full Text »  |  PDF »

Leukotriene B4 Strongly Increases Monocyte Chemoattractant Protein-1 in Human Monocytes.

L. Huang, A. Zhao, F. Wong, J. M. Ayala, M. Struthers, F. Ujjainwalla, S. D. Wright, M. S. Springer, J. Evans, and J. Cui (2004)
Arterioscler. Thromb. Vasc. Biol. 24, 1783-1788
 |  Abstract »  |  Full Text »  |  PDF »

A Century of Asthma.

E. R. McFadden Jr. (2004)
Am. J. Respir. Crit. Care Med. 170, 215-221
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Reduction of Renal Ischemia-Reperfusion Injury in 5-Lipoxygenase Knockout Mice and by the 5-Lipoxygenase Inhibitor Zileuton.

N. S. A. Patel, S. Cuzzocrea, P. K. Chatterjee, R. Di Paola, L. Sautebin, D. Britti, and C. Thiemermann (2004)
Mol. Pharmacol. 66, 220-227
 |  Abstract »  |  Full Text »  |  PDF »

E-Prostanoid-3 Receptors Mediate the Proinflammatory Actions of Prostaglandin E2 in Acute Cutaneous Inflammation.

J. L. Goulet, A. J. Pace, M. L. Key, R. S. Byrum, M. Nguyen, S. L. Tilley, S. G. Morham, R. Langenbach, J. L. Stock, J. D. McNeish, et al. (2004)
J. Immunol. 173, 1321-1326
 |  Abstract »  |  Full Text »  |  PDF »

Endotoxin-Induced Uveitis in Cyclooxygenase-2-Deficient Mice.

J. Tuo, N. Tuaillon, D. Shen, and C.-C. Chan (2004)
Invest. Ophthalmol. Vis. Sci. 45, 2306-2313
 |  Abstract »  |  Full Text »  |  PDF »

Leukotriene A4 Hydrolase: IDENTIFICATION OF A COMMON CARBOXYLATE RECOGNITION SITE FOR THE EPOXIDE HYDROLASE AND AMINOPEPTIDASE SUBSTRATES.

P. C. Rudberg, F. Tholander, M. Andberg, M. M. G. M. Thunnissen, and J. Z. Haeggstrom (2004)
J. Biol. Chem. 279, 27376-27382
 |  Abstract »  |  Full Text »  |  PDF »

Structural Basis of Leukotriene B4 12-Hydroxydehydrogenase/15-Oxo-prostaglandin 13-Reductase Catalytic Mechanism and a Possible Src Homology 3 Domain Binding Loop.

T. Hori, T. Yokomizo, H. Ago, M. Sugahara, G. Ueno, M. Yamamoto, T. Kumasaka, T. Shimizu, and M. Miyano (2004)
J. Biol. Chem. 279, 22615-22623
 |  Abstract »  |  Full Text »  |  PDF »

Arachidonate 5-Lipoxygenase Promoter Genotype, Dietary Arachidonic Acid, and Atherosclerosis.

J. H. Dwyer, H. Allayee, K. M. Dwyer, J. Fan, H. Wu, R. Mar, A. J. Lusis, and M. Mehrabian (2004)
N. Engl. J. Med. 350, 29-37
 |  Abstract »  |  Full Text »  |  PDF »

Imbalance Between Lipoxin A4 and Leukotriene B4 in Chronic Mastitis-Affected Cows.

P. Boutet, F. Bureau, G. Degand, and P. Lekeux (2003)
J Dairy Sci 86, 3430-3439
 |  Abstract »  |  Full Text »  |  PDF »

Toxicity of human monocytic THP-1 cells and microglia toward SH-SY5Y neuroblastoma cells is reduced by inhibitors of 5-lipoxygenase and its activating protein FLAP.

A. Klegeris and P. L. McGeer (2003)
J. Leukoc. Biol. 73, 369-378
 |  Abstract »  |  Full Text »  |  PDF »

International Union of Pharmacology XXXVII. Nomenclature for Leukotriene and Lipoxin Receptors.

C. Brink, S.-E. Dahlen, J. Drazen, J. F. Evans, D. W. P. Hay, S. Nicosia, C. N. Serhan, T. Shimizu, and T. Yokomizo (2003)
Pharmacol. Rev. 55, 195-227
 |  Abstract »  |  Full Text »  |  PDF »

Eosinophilic oesophagitis: a novel treatment using Montelukast.

S E A Attwood, C J Lewis, C S Bronder, C D Morris, G R Armstrong, and J Whittam (2003)
Gut 52, 181-185
 |  Abstract »  |  Full Text »  |  PDF »

Distribution of therapeutic response in asthma control between oral montelukast and inhaled beclomethasone.

R.A. Baumgartner, G. Martinez, J.M. Edelman, G.G. Rodriguez Gomez, M. Bernstein, S. Bird, R. Angner, A. Polis, S.B. Dass, S. Lu, et al. (2003)
Eur. Respir. J. 21, 123-128
 |  Abstract »  |  Full Text »  |  PDF »

Cell type-dependent activation of 5-lipoxygenase by arachidonic acid.

E. Burkert, D. Szellas, O. Radmark, D. Steinhilber, and O. Werz (2003)
J. Leukoc. Biol. 73, 191-200
 |  Abstract »  |  Full Text »  |  PDF »

The Yin and the Yang of 5-Lipoxygenase Pathway Activation.

T. D. Bigby (2002)
Mol. Pharmacol. 62, 200-202
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Characterization of Mouse Cysteinyl Leukotriene Receptors mCysLT1 and mCysLT2. DIFFERENTIAL PHARMACOLOGICAL PROPERTIES AND TISSUE DISTRIBUTION.

H. Ogasawara, S. Ishii, T. Yokomizo, T. Kakinuma, M. Komine, K. Tamaki, T. Shimizu, and T. Izumi (2002)
J. Biol. Chem. 277, 18763-18768
 |  Abstract »  |  Full Text »  |  PDF »

Leukotriene A4 hydrolase: Selective abrogation of leukotriene B4 formation by mutation of aspartic acid 375.

P. C. Rudberg, F. Tholander, M. M. G. M. Thunnissen, B. Samuelsson, and J. Z. Haeggstrom (2002)
PNAS 99, 4215-4220
 |  Abstract »  |  Full Text »  |  PDF »

Cloning and Functional Analysis of the Mouse 5-Lipoxygenase Promoter.

E. S. Silverman, L. Le, R. M. Baron, A. Hallock, J. Hjoberg, T. Shikanai, K. Storm van's Gravesande, P. E. Auron, and W. Lu (2002)
Am. J. Respir. Cell Mol. Biol. 26, 475-483
 |  Abstract »  |  Full Text »  |  PDF »

Hypertonicity suppresses ionophore-induced product formation and translocation of 5-lipoxygenase in human leukocytes.

E. Burkert, O. Radmark, B. Samuelsson, D. Steinhilber, and O. Werz (2002)
J. Leukoc. Biol. 71, 477-486
 |  Abstract »  |  Full Text »  |  PDF »

Leukotriene B4 Receptor Antagonism Reduces Monocytic Foam Cells in Mice.

R. J. Aiello, P.-A. Bourassa, S. Lindsey, W. Weng, A. Freeman, and H. J. Showell (2002)
Arterioscler. Thromb. Vasc. Biol. 22, 443-449
 |  Abstract »  |  Full Text »  |  PDF »

Formation of Murine Macrophage-derived 5-Oxo-7-glutathionyl-8,11,14-eicosatrienoic acid (FOG7) Is Catalyzed by Leukotriene C4 Synthase.

J. M. Hevko and R. C. Murphy (2002)
J. Biol. Chem. 277, 7037-7043
 |  Abstract »  |  Full Text »  |  PDF »

Effects of inhibitors of the lipo-oxygenase family of enzymes on the store-operated calcium current ICRAC in rat basophilic leukaemia cells.

M. D Glitsch, D. Bakowski, and A. B Parekh (2002)
J. Physiol. 539, 93-106
 |  Abstract »  |  Full Text »  |  PDF »

Leukotriene D4 activates MAPK through a Ras-independent but PKC{epsilon}-dependent pathway in intestinal epithelial cells.

S. Paruchuri, B. Hallberg, M. Juhas, C. Larsson, and A. Sjolander (2002)
J. Cell Sci. 115, 1883-1893
 |  Abstract »  |  Full Text »  |  PDF »

Deficiency of 5-Lipoxygenase Accelerates Renal Allograft Rejection in Mice.

J. L. Goulet, R. C. Griffiths, P. Ruiz, R. B. Mannon, P. Flannery, J. L. Platt, B. H. Koller, and T. M. Coffman (2001)
J. Immunol. 167, 6631-6636
 |  Abstract »  |  Full Text »  |  PDF »

Prostaglandins and Leukotrienes: Advances in Eicosanoid Biology.

C. D. Funk (2001)
Science 294, 1871-1875
 |  Abstract »  |  Full Text »  |  PDF »

Pharmacokinetics and Metabolism of a Cysteinyl Leukotriene-1 Receptor Antagonist from the Heterocyclic Chromanol Series in Rats: In Vitro-In Vivo Correlation, Gender-Related Differences, Isoform Identification, and Comparison with Metabolism in Human Hepatic Tissue.

A. V. Kuperman, A. S. Kalgutkar, A. Marfat, R. J. Chambers, and T. E. Liston (2001)
Drug Metab. Dispos. 29, 1403-1409
 |  Abstract »  |  Full Text »  |  PDF »

Peroxynitrite-Induced Nitrotyrosination of Proteins Is Blocked by Direct 5-Lipoxygenase Inhibitor Zileuton.

M. J. Coffey, S. M. Phare, and M. Peters-Golden (2001)
J. Pharmacol. Exp. Ther. 299, 198-203
 |  Abstract »  |  Full Text »  |  PDF »

LtB4 Evokes the Calcium Signal That Initiates Nuclear Envelope Breakdown through a Multi-enzyme Network in Sand Dollar (Echinaracnius parma) Cells.

R. B. Silver (2001)
Biol. Bull. 201, 248-250
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Biology of Mucosal Pain.

C. Miaskowski (2001)
J Natl Cancer Inst Monographs 2001, 37-40
 |  Abstract »  |  Full Text »  |  PDF »

Induction of Hepatic Microsomal Drug-Metabolizing Enzymes by Inhibitors of 5-Lipoxygenase (5-LO): Studies in Rats and 5-LO Knockout Mice.

W. P. Beierschmitt, J. D. McNeish, R. J. Griffiths, A. Nagahisa, M. Nakane, and D. E. Amacher (2001)
Toxicol. Sci. 63, 15-21
 |  Abstract »  |  Full Text »  |  PDF »

A Pertussis Toxin-Sensitive 8-Lipoxygenase Pathway Is Activated by a Nicotinic Acetylcholine Receptor in Aplysia Neurons.

T. L. Tieman, D. J. Steel, Y. Gor, J. Kehoe, J. H. Schwartz, and S. J. Feinmark (2001)
J Neurophysiol 85, 2150-2158
 |  Abstract »  |  Full Text »  |  PDF »

Phorbol ester up-regulates capacities for nuclear translocation and phosphorylation of 5-lipoxygenase in Mono Mac 6 cells and human polymorphonuclear leukocytes.

O. Werz, J. Klemm, B. Samuelsson, and O. Radmark (2001)
Blood 97, 2487-2495
 |  Abstract »  |  Full Text »  |  PDF »

Expression of the Cysteinyl Leukotriene 1 Receptor in Normal Human Lung and Peripheral Blood Leukocytes.

D. J. FIGUEROA, R. M. BREYER, S. K. DEFOE, S. KARGMAN, B. L. DAUGHERTY, K. WALDBURGER, Q. LIU, M. CLEMENTS, Z. ZENG, G. P. O'NEILL, et al. (2001)
Am. J. Respir. Crit. Care Med. 163, 226-233
 |  Abstract »  |  Full Text »

Comparison of Montelukast and Fexofenadine for Chronic Idiopathic Urticaria.

E. Nettis, P. Dambra, L. D'Oronzio, M. P. Loria, A. Ferrannini, and A. Tursi (2001)
Arch Dermatol 137, 99-100
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Prolonged Exposure to Lipopolysaccharide Inhibits Macrophage 5-Lipoxygenase Metabolism Via Induction of Nitric Oxide Synthesis.

M. J. Coffey, S. M. Phare, and M. Peters-Golden (2000)
J. Immunol. 165, 3592-3598
 |  Abstract »  |  Full Text »  |  PDF »

Direct activation of capsaicin receptors by products of lipoxygenases: Endogenous capsaicin-like substances.

S. W. Hwang, H. Cho, J. Kwak, S.-Y. Lee, C.-J. Kang, J. Jung, S. Cho, K. H. Min, Y.-G. Suh, D. Kim, et al. (2000)
PNAS 97, 6155-6160
 |  Abstract »  |  Full Text »  |  PDF »

Genetic Factors Determine the Contribution of Leukotrienes to Acute Inflammatory Responses.

J. L. Goulet, R. S. Byrum, M. L. Key, M. Nguyen, V. A. Wagoner, and B. H. Koller (2000)
J. Immunol. 164, 4899-4907
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Comparison of the effects of intravenous and oral montelukast on airway function: a double blind, placebo controlled, three period, crossover study in asthmatic patients.

R J Dockhorn, R A Baumgartner, J A Leff, M Noonan, K Vandormael, W Stricker, D E Weinland, and T F Reiss (2000)
Thorax 55, 260-265
 |  Abstract »  |  Full Text »

Leukotriene D4 Triggers an Association between Gbeta gamma Subunits and Phospholipase C-gamma 1 in Intestinal Epithelial Cells.

C. K. Thodeti, J. Adolfsson, M. Juhas, and A. Sjolander (2000)
J. Biol. Chem. 275, 9849-9853
 |  Abstract »  |  Full Text »  |  PDF »

The Discovery of the Leukotrienes.

B. SAMUELSSON (2000)
Am. J. Respir. Crit. Care Med. 161, S2-6
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The Molecular Biology and Regulation of 5-Lipoxygenase.

O. P. RADMARK (2000)
Am. J. Respir. Crit. Care Med. 161, S11-15
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Membrane-associated Proteins in Eicosanoid and Glutathione Metabolism (MAPEG) . A Widespread Protein Superfamily.

P.-J. JAKOBSSON, R. MORGENSTERN, J. MANCINI, A. FORD-HUTCHINSON, and B. PERSSON (2000)
Am. J. Respir. Crit. Care Med. 161, S20-24
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Structure, Function, and Regulation of Leukotriene A4 Hydrolase.

J. Z. HAEGGSTROM (2000)
Am. J. Respir. Crit. Care Med. 161, S25-31
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Cloning of a Novel Chemoattractant Receptor Activated by Leukotriene B4 and Used by Human Immunodeficiency Virus Type 1 to Infect CD4-positive Immune Cells . A Therapeutic Connection to Asthma?.

C. OWMAN, A. SABIRSH, A. GARZINO-DEMO, and F. COCCHI (2000)
Am. J. Respir. Crit. Care Med. 161, S56-61
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Leukotriene Bronchoconstriction Induced by Allergen and Exercise.

P. M. O'BYRNE (2000)
Am. J. Respir. Crit. Care Med. 161, S68-72
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Contribution of Ras GTPase/MAP Kinase and Cytochrome P450 Metabolites to Deoxycorticosterone-Salt-Induced Hypertension.

M. M. Muthalif, I. F. Benter, Z. Khandekar, L. Gaber, A. Estes, S. Malik, J.-H. Parmentier, V. Manne, and K. U. Malik (2000)
Hypertension 35, 457-463
 |  Abstract »  |  Full Text »  |  PDF »

Cloning and Characterization of a Bifunctional Leukotriene A4 Hydrolase from Saccharomyces cerevisiae.

F. Kull, E. Ohlson, and J. Z. Haeggstrom (1999)
J. Biol. Chem. 274, 34683-34690
 |  Abstract »  |  Full Text »  |  PDF »

Human placental cells show enhanced production of interleukin (IL)-8 in response to lipopolysaccharide (LPS), IL-1 and tumour necrosis factor (TNF)-{alpha}, but not to IL-6.

K. Shimoya, A. Moriyama, N. Matsuzaki, I. Ogata, M. Koyama, C. Azuma, F. Saji, and Y. Murata (1999)
Mol. Hum. Reprod. 5, 885
 |  Abstract »  |  Full Text »  |  PDF »

Effects of Lipid Mediator Antagonists on Predominant Mediator-Controlled Asthmatic Reactions in Passively Sensitized Guinea Pigs.

Y. Arakida, K. Ohga, K. Suwa, M. Yokota, K. Miyata, T. Yamada, and K. Honda (1999)
J. Pharmacol. Exp. Ther. 290, 1285-1291
 |  Abstract »  |  Full Text »

ACCELERATED COMMUNICATION: Identification, Molecular Cloning, Expression, and Characterization of a Cysteinyl Leukotriene Receptor.

H. M. Sarau, R. S. Ames, J. Chambers, C. Ellis, N. Elshourbagy, J. J. Foley, D. B. Schmidt, R. M. Muccitelli, O. Jenkins, P. R. Murdock, et al. (1999)
Mol. Pharmacol. 56, 657-663
 |  Abstract »  |  Full Text »

Deficiency of 5-Lipoxygenase Abolishes Sex-Related Survival Differences in MRL-lpr/lpr Mice.

J. L. Goulet, R. C. Griffiths, P. Ruiz, R. F. Spurney, D. S. Pisetsky, B. H. Koller, and T. M. Coffman (1999)
J. Immunol. 163, 359-366
 |  Abstract »  |  Full Text »  |  PDF »

Cytosolic phospholipase A2 is essential for both the immediate and the delayed phases of eicosanoid generation in mouse bone marrow-derived mast cells.

H. Fujishima, R. O. Sanchez Mejia, C. O. Bingham III, B. K. Lam, A. Sapirstein, J. V. Bonventre, K. F. Austen, and J. P. Arm (1999)
PNAS 96, 4803-4807
 |  Abstract »  |  Full Text »  |  PDF »

Leukotriene Binding, Signaling, and Analysis of HIV Coreceptor Function in Mouse and Human Leukotriene B4 Receptor-transfected Cells.

V. Martin, P. Ronde, D. Unett, A. Wong, T. L. Hoffman, A. L. Edinger, R. W. Doms, and C. D. Funk (1999)
J. Biol. Chem. 274, 8597-8603
 |  Abstract »  |  Full Text »  |  PDF »

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