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Science 29 April 1983:
Vol. 220. no. 4596, pp. 536 - 537
DOI: 10.1126/science.6836300
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Articles

Science, Vol 220, Issue 4596, 536-537
Copyright © 1983 by American Association for the Advancement of Science

articles

Synaptic activity mediates death of hypoxic neurons

SM Rothman

Cultured hippocampal neurons, when exposed to cyanide or an anoxic atmosphere in the early stages of differentiation, were not visibly affected. However, neurons in the mature cultures died when exposed to cyanide or anoxia. Cell death could be prevented by treatment with magnesium, which eliminates synaptic activity. These observations suggest that damage in hypoxic neurons is mediated by synaptic activity.


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