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Science 29 April 1983:
Vol. 220. no. 4596, pp. 534 - 536
DOI: 10.1126/science.6836299
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Articles

Science, Vol 220, Issue 4596, 534-536
Copyright © 1983 by American Association for the Advancement of Science

articles

Pregnancy increases reactivity of mice to phenobarbital

LD Middaugh, JW Zemp, and WO Boggan

Compared to nonpregnant controls, pregnant mice injected with phenobarbital had lower concentrations of the drug in the plasma but equivalent concentrations in the brain. In spite of the similar concentrations in the brain, the behavioral response to phenobarbital was greater for pregnant than nonpregnant mice. These results suggest that the concentration of phenobarbital in the plasma, which is commonly used as a basis for adjusting phenobarbital dosage during pregnancy, is not an appropriate indicator of the dynamics of the drug.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)