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Science 29 April 1983:
Vol. 220. no. 4596, pp. 522 - 524
DOI: 10.1126/science.6403985
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Articles

Science, Vol 220, Issue 4596, 522-524
Copyright © 1983 by American Association for the Advancement of Science

articles

Bovine x mouse hybridomas that secrete bovine immunoglobulin G1

S Srikumaran, AJ Guidry, and RA Goldsby

The interspecific fusion of normal bovine lymphocytes with a nonsecreting mouse hybridoma produced stable cell lines secreting bovine immunoglobulins. One of these lines has continued to secrete immunoglobulin G1 (5 to 10 micrograms per milliliter) for over 16 months. The bovine x mouse hybrid cells can be expected to provide bovine monoclonal immunoglobulins for sequencing studies and for use as serological standards as well as to provide messenger RNA for cloning bovine immunoglobulin genes.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)