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Science 29 April 1983:
Vol. 220. no. 4596, pp. 521 - 522
DOI: 10.1126/science.6573023
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Articles

Science, Vol 220, Issue 4596, 521-522
Copyright © 1983 by American Association for the Advancement of Science

articles

Stimulation of prostaglandin biosynthesis by urine of the human fetus may serve as a trigger for parturition

DM Strickland, SA Saeed, ML Casey, and MD Mitchell

Urine of the human fetus stimulated prostaglandin biosynthesis in vitro by increasing the conversion of arachidonic acid into prostaglandins. The stimulatory activity in urine from fetuses delivered at term after labor of spontaneous onset was greater than that in urine from fetuses delivered by cesarean section at term before the onset of labor. Such stimulation of prostaglandin biosynthesis by the fetal membranes, by way of a substance released into the urine and thence into amniotic fluid, could serve as a signal for the initiation of parturition.


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