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Science 29 April 1983:
Vol. 220. no. 4596, pp. 505 - 507
DOI: 10.1126/science.6301010
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Articles

Science, Vol 220, Issue 4596, 505-507
Copyright © 1983 by American Association for the Advancement of Science

articles

Hemagglutinin variants of reovirus type 3 have altered central nervous system tropism

DR Spriggs, RT Bronson, and BN Fields

Variants of the Dearing strain of reovirus type 3 with antigenically altered hemagglutinin proteins are much less neurovirulent than the parental virus. When injected intracerebrally into mice these variants infected a subset of the brain neurons that were infected by the parental virus. When injected intraperitoneally, the variants did not spread to the brain. These results indicate that minor modifications of the reovirus hemagglutinin dramatically alter the ability of the virus to spread into and injure the central nervous system.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Junctional Adhesion Molecule A Serves as a Receptor for Prototype and Field-Isolate Strains of Mammalian Reovirus.
J. A. Campbell, P. Schelling, J. D. Wetzel, E. M. Johnson, J. C. Forrest, G. A. R. Wilson, M. Aurrand-Lions, B. A. Imhof, T. Stehle, and T. S. Dermody (2005)
J. Virol. 79, 7967-7978
   Abstract »    Full Text »    PDF »
Regional Differences in Viral Growth and Central Nervous System Injury Correlate with Apoptosis.
S. M. Richardson-Burns and K. L. Tyler (2004)
J. Virol. 78, 5466-5475
   Abstract »    Full Text »    PDF »
Identification of Carbohydrate-Binding Domains in the Attachment Proteins of Type 1 and Type 3 Reoviruses.
J. D. Chappell, J. L. Duong, B. W. Wright, and T. S. Dermody (2000)
J. Virol. 74, 8472-8479
   Abstract »    Full Text »
How Do Viruses Cause Different Diseases?.
B. N. Fields (1983)
JAMA 250, 1754-1756
   Abstract »    PDF »


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