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Science 22 April 1983:
Vol. 220. no. 4595, pp. 411 - 413
DOI: 10.1126/science.6836283
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Articles

Science, Vol 220, Issue 4595, 411-413
Copyright © 1983 by American Association for the Advancement of Science

articles

Desickling of sickled erythrocytes by pulsed radio-frequency field

S Takashima and T Asakura

Electric fields were found to deform sickled erythrocytes. When the intensity of applied fields exceeded a threshold value, sickled erythrocytes transformed into a spherical shape. Prolonged application of the field usually caused hemolysis of erythrocytes. Deformation of red blood cells could be partly reversed if the field was turned off at an early stage. The cause of desickling may be the interaction of the field with the erythrocyte membrane and also with gelled intracellular hemoglobin S molecules.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)