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Science 15 April 1983:
Vol. 220. no. 4594, pp. 331 - 333
DOI: 10.1126/science.6836278
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Articles

Science, Vol 220, Issue 4594, 331-333
Copyright © 1983 by American Association for the Advancement of Science

articles

Alcohol-induced spasms of cerebral blood vessels: relation to cerebrovascular accidents and sudden death

BM Altura, BT Altura, and A Gebrewold

Ethyl alcohol produced graded contractile responses in rat cerebral arterioles and venules in vivo and in isolated canine basilar and middle cerebral arteries at a concentration range (10 to 500 milligrams per deciliter) which parallels that needed for its graded effects of euphoria, mental haziness, muscular incoordination, stupor, and coma in humans. Two specific calcium antagonists, nimodipine and verapamil, prevented or reversed the alcohol-induced cerebrovasospasm and thus may prove valuable in treating the hypertension and stroke observed in heavy users of alcohol.


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