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Science 15 April 1983:
Vol. 220. no. 4594, pp. 323 - 325
DOI: 10.1126/science.6301005
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Articles
Science, Vol 220, Issue 4594, 323-325
Copyright © 1983 by American Association for the Advancement of Science
Systemic cholinergic agents induce seizures and brain damage in lithium-treated rats
MP Honchar,
JW Olney,
and
WR Sherman
Administration of pilocarpine or physostigmine to rats treated with lithium chloride produced sustained limbic seizures, widespread brain damage, and increased concentrations of D-myo-inositol-1-phosphate (a metabolite of the phosphoinositides, lipids involved in membrane receptor function) in the brain. The syndrome was preventable with atropine. The physostigmine doses and concentrations of blood lithium that caused the syndrome are similar to those considered appropriate for psychiatric chemotherapy.
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