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Science 15 April 1983:
Vol. 220. no. 4594, pp. 304 - 306
DOI: 10.1126/science.6301002
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Articles

Science, Vol 220, Issue 4594, 304-306
Copyright © 1983 by American Association for the Advancement of Science

articles

Virus-induced autoimmunity: monoclonal antibodies that react with endocrine tissues

MV Haspel, T Onodera, BS Prabhakar, M Horita, H Suzuki, and AL Notkins

Mice infected with reovirus type 1 develop an autoimmune polyendocrine disease. Spleen cells from these mice were fused with myeloma cells and the culture fluids were screened by indirect immunofluorescence for autoantibodies reactive with normal mouse tissues. A large panel of cloned, stable antibody-producing hybridomas has been obtained. Fourteen of the hybridomas make autoantibodies that react with cells in the islets of Langerhans, 24 with cells in the anterior pituitary, 11 with cells in gastric mucosa, and 5 with nuclei. Except for the antibodies to nuclei, the monoclonal autoantibodies are organ-specific. Some, however, show broad cross-species reactivity, recognizing similar antigenic determinants in mouse, rat, pig, and human organs, whereas other recognize determinants only in rodent tissues. Several of the antigens recognized by these monoclonal autoantibodies have been identified as hormones (for example, glucagon, growth hormone, and insulin).


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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J. D. Wetzel, E. S. Barton, J. D. Chappell, G. S. Baer, M. Mochow-Grundy, S. E. Rodgers, Y. Shyr, A. C. Powers, J. W. Thomas, and T. S. Dermody (2006)
J. Virol. 80, 3078-3082
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Endocrine Aspects of Cancer Gene Therapy.
L. Barzon, M. Boscaro, and G. Palu (2004)
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Polyglandular Autoimmune Syndromes: Immunogenetics and Long-Term Follow-Up.
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J. Clin. Endocrinol. Metab. 88, 2983-2992
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Autoimmune Adrenal Insufficiency and Autoimmune Polyendocrine Syndromes: Autoantibodies, Autoantigens, and Their Applicability in Diagnosis and Disease Prediction.
C. Betterle, C. Dal Pra, F. Mantero, and R. Zanchetta (2002)
Endocr. Rev. 23, 327-364
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Exacerbation of Autoantibody-Mediated Hemolytic Anemia by Viral Infection.
M. Meite, S. Léonard, M. E. A. E. Idrissi, S. Izui, P. L. Masson, and J.-P. Coutelier (2000)
J. Virol. 74, 6045-6049
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Retrovirus-Mediated Myelopathies: Are These Autoimmune Disorders Induced by Altered Antigens?.
M. M. Gore, J. P. Thakare, S. N. Ghosh, and R. S. Wadia (1988)
Arch Neurol 45, 601-602
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Amino acid homology between the encephalitogenic site of myelin basic protein and virus: mechanism for autoimmunity.
R. Fujinami and M. Oldstone (1985)
Science 230, 1043-1045
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Specific endocrine tissue marker defined by a monoclonal antibody.
R. Lloyd and B. Wilson (1983)
Science 222, 628-630
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