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Science 8 April 1983:
Vol. 220. no. 4593, pp. 210 - 212
DOI: 10.1126/science.6828888
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Articles

Science, Vol 220, Issue 4593, 210-212
Copyright © 1983 by American Association for the Advancement of Science

articles

Regulation of the macrophage content of neoplasms by chemoattractants

B Bottazzi, N Polentarutti, R Acero, A Balsari, D Boraschi, P Ghezzi, M Salmona, and A Mantovani

Factor chemotactic for mononuclear phagocytes was found in supernatant fluids of cultured human and mouse tumor cells. In 11 mouse tumors there was a correlation observed between chemotactic activity and macrophage content of neoplastic tissues. Tumor-derived chemoattractants appear to participate in the regulation of tumor-associated macrophages.


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